Research output per year
Research output per year
Search results
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2025
Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma
Jin, Y., Zhang, B., Li, J., Guo, Z., Zhang, C., Chen, X., Ma, L., Wang, Z., Yang, H., Li, Y., Weng, Y., Huang, Y., Yan, X. & Fan, K., 21 Feb 2025, In: Science advances. 11, 8, eadr9266.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Correction to “Photoactivatable Silencing Extracellular Vesicle (PASEV) Sensitizes Cancer Immunotherapy”(Adv. Mater., (2022), 34, (2204765), 10.1002/adma.202204765)
Lu, M., Xing, H., Shao, W., Zhang, T., Zhang, M., Wang, Y., Li, F., Weng, Y., Zheng, A., Huang, Y. & Liang, X. J., 2025, (Accepted/In press) In: Advanced Materials.Research output: Contribution to journal › Comment/debate
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Nanocarrier vaccines for respiratory infections
Jiang, Y., Lei, L., Zhao, M., Tian, Y., Huang, Y. & Yang, M., 2025, (Accepted/In press) In: Trends in Molecular Medicine.Research output: Contribution to journal › Review article › peer-review
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NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing and immunogenic cell death
Zhang, T., Tang, D., Wu, P., Jiang, S., Zhang, Y., Naeem, A., Li, Y., Li, C., Hu, B., Guo, S., Sun, C., Xiao, H., Yan, R., Weng, Y. & Huang, Y., Apr 2025, In: Bioactive Materials. 46, p. 285-300 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma
Li, Z., Jiang, S., Wang, J., Li, W., Yang, J., Liu, W., Gao, H., Huang, Y. & Ruan, S., 17 Jan 2025, In: Science advances. 11, 3, eadr7934.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
核酸驱动蛋白质降解:溶酶体靶向降解技术前沿
Translated title of the contribution: Nucleic Acid-driven Protein Degradation: Frontiers of Lysosomal Targeted Degradation TechnologyYin, H., Li, Y., Fan, Y. C., Guo, S., Huang, Y. Y., Li, Y. & Weng, Y. H., 28 Jan 2025, In: Progress in Biochemistry and Biophysics. 52, 1, p. 5-19 15 p.Research output: Contribution to journal › Review article › peer-review
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2024
An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus
Tian, Y., Li, M., Yang, Y., Li, C., Peng, Y., Yang, H., Zhao, M., Wu, P., Ruan, S., Huang, Y., Shen, C. & Yang, M., Aug 2024, In: Chinese Chemical Letters. 35, 8, 109270.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential anti pan-coronavirus activity
Yang, M., Li, C., Ye, G., Shen, C., Shi, H., Zhong, L., Tian, Y., Zhao, M., Wu, P., Hussain, A., Zhang, T., Yang, H., Yang, J., Weng, Y., Liu, X., Wang, Z., Gan, L., Zhang, Q., Liu, Y. & Yang, G. & 2 others, , Dec 2024, In: Signal Transduction and Targeted Therapy. 9, 1, 40.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA
Zhang, M., Hussain, A., Hu, B., Yang, H., Li, C., Guo, S., Han, X., Li, B., Dai, Y., Cao, Y., Chi, H., Weng, Y., Qin, C. F. & Huang, Y., Dec 2024, In: Nature Communications. 15, 1, 6463.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma
Jiang, S., Li, W., Yang, J., Zhang, T., Zhang, Y., Xu, L., Hu, B., Li, Z., Gao, H., Huang, Y. & Ruan, S., 27 Feb 2024, In: ACS Nano. 18, 8, p. 6445-6462 18 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Delivery and therapeutic application of neutralizing antibodies
Li, Q., Xing, H., Zheng, A., Huang, Y. & Lu, M., 2 Apr 2024, Neutralizing Antibodies and their Role in Health and Disease. Nova Science Publishers, Inc., p. 25-67 43 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Development of Glycan-masked SARS-CoV-2 RBD vaccines against SARS-related coronaviruses
Liang, Z., Li, C., Gong, X., Ye, G., Jiang, Y., Shi, H., Hussain, A., Zhao, M., Li, M., Tian, Y., Zhao, W., Yang, Y., Huang, Y., Shen, C. & Yang, M., Sept 2024, In: PLoS Pathogens. 20, 9, e1012599.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma
Yang, J., Li, Y., Jiang, S., Tian, Y., Zhang, M., Guo, S., Wu, P., Li, J., Xu, L., Li, W., Wang, Y., Gao, H., Huang, Y., Weng, Y. & Ruan, S., 2024, (Accepted/In press) In: Exploration.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Engineered extracellular vesicles as a next-generation vaccine platform
Lu, M., Xing, H., Zhao, X., Huang, Y., Zheng, A. & Liang, X. J., 4 Dec 2024, In: Matter. 7, 12, p. 4180-4205 26 p.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Exosome regulation of immune response mechanism: Pros and cons in immunotherapy
Essola, J. M., Zhang, M., Yang, H., Li, F., Xia, B., Mavoungou, J. F., Hussain, A. & Huang, Y., Feb 2024, In: Bioactive Materials. 32, p. 124-146 23 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Citations (Scopus) -
Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention
Li, Z., Li, W., Jiang, S., Hu, C., Huang, Y., Shevtsov, M., Gao, H. & Ruan, S., Jul 2024, In: Chinese Chemical Letters. 35, 7, 109150.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
mRNA疫苗与脂质纳米颗粒递送载体的研究进展
Translated title of the contribution: Progress on mRNA vaccines and lipid nanoparticlesFan, Y., Yin, H., Li, Y., Yu, X., Tang, X., Weng, Y. & Huang, Y., 2024, In: Kexue Tongbao/Chinese Science Bulletin. 69, 33, p. 4813-4823 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo
Zhang, T., Yin, H., Li, Y., Yang, H., Ge, K., Zhang, J., Yuan, Q., Dai, X., Naeem, A., Weng, Y., Huang, Y. & Liang, X. J., 21 Jun 2024, In: iScience. 27, 6, 109804.Research output: Contribution to journal › Review article › peer-review
Open Access12 Citations (Scopus) -
pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy
Guo, S., Li, C., Wang, C., Cao, X., Liu, X., Liang, X. J., Huang, Y. & Weng, Y., Feb 2024, In: Acta Pharmaceutica Sinica B. 14, 2, p. 781-794 14 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
Protocol for in vivo nucleic acid delivery utilizing the rolling microneedle electrode array
Wu, P., Yang, T., Huang, D., Zhang, T., Naeem, A., Ren, Y., Wang, Y., Li, Z., Huang, Y., Li, Y. & Weng, Y., 20 Sept 2024, In: STAR Protocols. 5, 3, 103261.Research output: Contribution to journal › Article › peer-review
Open Access -
Recent progresses of exosome–liposome fusions in drug delivery
Zheng, L., Hu, B., Zhao, D., Liu, W., Liu, Q., Huang, Y. & Ruan, S., Feb 2024, In: Chinese Chemical Letters. 35, 2, 108647.Research output: Contribution to journal › Review article › peer-review
16 Citations (Scopus) -
Spatiotemporal-Controlled NIR-II Immune Agonist Sensitizes Cancer Immunotherapy
Guo, S., Tang, D., Zhang, M., Yang, H., Zhang, T., Hu, B., Xu, C., Weng, Y., Shang, K. & Huang, Y., 20 Jun 2024, In: Advanced Materials. 36, 25, 2400228.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Targeted reprogramming of tumor-associated macrophages for overcoming glioblastoma resistance to chemotherapy and immunotherapy
Li, J., Yang, J., Jiang, S., Tian, Y., Zhang, Y., Xu, L., Hu, B., Shi, H., Li, Z., Ran, G., Huang, Y. & Ruan, S., Dec 2024, In: Biomaterials. 311, 122708.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
The landscape of nanoparticle-based siRNA delivery and therapeutic development
Moazzam, M., Zhang, M., Hussain, A., Yu, X., Huang, J. & Huang, Y., 7 Feb 2024, In: Molecular Therapy. 32, 2, p. 284-312 29 p.Research output: Contribution to journal › Review article › peer-review
42 Citations (Scopus) -
Three ‘E’ challenges for siRNA drug development
Guo, S., Zhang, M. & Huang, Y., Jan 2024, In: Trends in Molecular Medicine. 30, 1, p. 13-24 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access22 Citations (Scopus) -
Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy
Huang, Z., Yang, T., Yu, J., Gao, Y., Weng, Y., Huang, Y. & Li, S., 2024, (Accepted/In press) In: Biomaterials Science.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
猴痘病毒mRNA疫苗的研发进展
Translated title of the contribution: Advancements in the development of mRNA vaccine against monkeypox virusLiu, X., Hu, B., Fan, Y., Weng, Y., Huang, Y. & Yang, M., 2024, In: Kexue Tongbao/Chinese Science Bulletin. 69, 33, p. 4789-4794 6 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
纳米技术在肿瘤嵌合抗原受体 T 细胞疗法中的应用
Translated title of the contribution: Application of Nanotechnology in CAR-T-based Cancer TherapyXu, L., Hu, B., Zheng, L. L., Jiang, S. P., Ruan, S. B. & Huang, Y. Y., 2024, In: Progress in Biochemistry and Biophysics. 51, 12, p. 3103-3122 20 p.Research output: Contribution to journal › Article › peer-review
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脂质纳米颗粒递送 mRNA 在疾病防治中的应用
Translated title of the contribution: The Application of Lipid Nanoparticle-delivered mRNA in Disease Prevention and TreatmentSun, W. L., Zhou, T. Q., Yang, H. Y., Li, L. W., Weng, Y. H., Zhang, J. C., Huang, Y. Y. & Liang, X. J., 2024, In: Progress in Biochemistry and Biophysics. 51, 10, p. 2677-2693 17 p.Research output: Contribution to journal › Review article › peer-review
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2023
A DNA-based nanodevice for near-infrared light-controlled drug release and bioimaging
Liu, Q., Cheng, H. B., Ma, R., Yu, M., Huang, Y., Li, L. & Zhao, J., Feb 2023, In: Nano Today. 48, 101747.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus) -
Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment
Liu, R., Luo, C., Pang, Z., Zhang, J., Ruan, S., Wu, M., Wang, L., Sun, T., Li, N., Han, L., Shi, J., Huang, Y., Guo, W., Peng, S., Zhou, W. & Gao, H., Feb 2023, In: Chinese Chemical Letters. 34, 2, 107518.Research output: Contribution to journal › Article › peer-review
368 Citations (Scopus) -
Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles
Lu, M., Xing, H., Shao, W., Wu, P., Fan, Y., He, H., Barth, S., Zheng, A., Liang, X. J. & Huang, Y., Sept 2023, In: Acta Pharmaceutica Sinica B. 13, 9, p. 3945-3955 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Aptamer and its selection via various SELEX strategies
Yang, G., Liu, W. & Huang, Y., 1 Jan 2023, Aptamers for Food Applications: Safety, Authenticity, and Integrity. Elsevier, p. 29-64 36 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR in Caenorhabditis elegans
Cong, W., Wang, Y., Yuan, C., Xu, M., Wang, H., Hu, Y., Dai, X., Weng, Y., Timashev, P., Liang, X. J. & Huang, Y., 2023, In: Theranostics. 13, 10, p. 3276-3289 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Endogenous Enzyme-Operated Spherical Nucleic Acids for Cell-Selective Protein Capture and Localization Regulation
Liu, Q., Huang, Y., Li, L., Li, Z. & Li, M., 24 Apr 2023, In: Angewandte Chemie - International Edition. 62, 18, e202214958.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Extracellular vesicle-based nucleic acid delivery
Lu, M., Shao, W., Xing, H. & Huang, Y., Apr 2023, In: Interdisciplinary Medicine. 1, 2, e20220007.Research output: Contribution to journal › Article › peer-review
Open Access30 Citations (Scopus) -
Ionizable drug delivery systems for efficient and selective gene therapy
Zhang, Y. Q., Guo, R. R., Chen, Y. H., Li, T. C., Du, W. Z., Xiang, R. W., Guan, J. B., Li, Y. P., Huang, Y. Y., Yu, Z. Q., Cai, Y., Zhang, P. & Ling, G. X., Dec 2023, In: Military Medical Research. 10, 1, 9.Research output: Contribution to journal › Review article › peer-review
Open Access14 Citations (Scopus) -
Lipid-conjugated siRNA hitchhikes endogenous albumin for tumor immunotherapy
Hu, B., Kong, S., Weng, Y., Zhao, D., Hussain, A., Jiao, Q., Zhan, S., Qiu, L., Lin, J., Xie, M., Li, B. & Huang, Y., Nov 2023, In: Chinese Chemical Letters. 34, 11, 108210.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Mitochondrial-mimicking nanozyme-catalyzed cascade reactions for aging attenuation
Cong, W., Meng, L., Pan, Y., Wang, H., Zhu, J., Huang, Y. & Huang, Q., Feb 2023, In: Nano Today. 48, 101757.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
mRNA-based modalities for infectious disease management
Zhang, M., Hussain, A., Yang, H., Zhang, J., Liang, X. J. & Huang, Y., Jan 2023, In: Nano Research. 16, 1, p. 672-691 20 p.Research output: Contribution to journal › Review article › peer-review
Open Access15 Citations (Scopus) -
Multi-walled carbon nanotubes reversing the bone formation of bone marrow stromal cells by activating M2 macrophage polarization
Lin, R., Ge, K., Fan, D., Li, J., Zhou, G., Zhang, K., Huang, Y., Ma, L. & Zhang, J., 2023, In: Regenerative Biomaterials. 10, rbad042.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Overcoming Pharmaceutical Bottlenecks for Nucleic Acid Drug Development
Lu, M., Xing, H., Zheng, A., Huang, Y. & Liang, X. J., 7 Feb 2023, In: Accounts of Chemical Research. 56, 3, p. 224-236 13 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Screening and Identification of ssDNA Aptamers for Low-Density Lipoprotein (LDL) Receptor-Related Protein 6
Zhang, X., Yang, G., Liu, W., Liu, Q., Wang, Z., Fan, K., Qu, F. & Huang, Y., May 2023, In: Molecules. 28, 9, 3838.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Selection and Identification of an ssDNA Aptamer for Fibroblast Activation Protein
Zhang, X., Yang, G., Zhao, Y., Dai, X., Liu, W., Qu, F. & Huang, Y., Feb 2023, In: Molecules. 28, 4, 1682.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
siRNA targeting ANGPTL3 stands in the spotlight for lipid-lowering therapy
Hu, B. & Huang, Y., 13 Jun 2023, In: Molecular Therapy Nucleic Acids. 32, p. 369-370 2 p.Research output: Contribution to journal › Comment/debate
Open Access3 Citations (Scopus) -
2022
Advanced Biomaterials for Cell-Specific Modulation and Restore of Cancer Immunotherapy
Ruan, S., Huang, Y., He, M. & Gao, H., 3 Jun 2022, In: Advanced Science. 9, 16, 2200027.Research output: Contribution to journal › Review article › peer-review
Open Access40 Citations (Scopus) -
Advances in mRNA Delivery and Clinical Applications
Hu, B., Hussain, A., Liu, Q., Weng, Y. & Huang, Y., 2022, RNA Technologies. Springer Science and Business Media Deutschland GmbH, p. 277-305 29 p. (RNA Technologies; vol. 13).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Citation (Scopus) -
An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor-Specific Activation of Signal Amplification in miRNA Imaging
Liu, Q., Huang, Y., Li, Z., Li, L., Zhao, Y. & Li, M., 19 Dec 2022, In: Angewandte Chemie - International Edition. 61, 51, e202214230.Research output: Contribution to journal › Article › peer-review
65 Citations (Scopus) -
Antibody–siRNA conjugates (ARC): Emerging siRNA drug formulation
Cao, W., Li, R., Pei, X., Chai, M., Sun, L., Huang, Y., Wang, J., Barth, S., Yu, F. & He, H., Sept 2022, In: Medicine in Drug Discovery. 15, 100128.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
Biosafety materials: Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system
Zhang, Y., Li, Z., Milon Essola, J., Ge, K., Dai, X., He, H., Xiao, H., Weng, Y. & Huang, Y., Apr 2022, In: Biosafety and Health. 4, 2, p. 70-78 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access14 Citations (Scopus)
