TY - JOUR
T1 - Nanocarrier vaccines for respiratory infections
AU - Jiang, Yinghan
AU - Lei, Luping
AU - Zhao, Mengyuan
AU - Tian, Yuxin
AU - Huang, Yuanyu
AU - Yang, Minghui
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2025
Y1 - 2025
N2 - Respiratory infections continue to pose a major global health challenge, leading to high morbidity and mortality. Effective vaccines are crucial for prevention of these, and nanotechnology offers a promising approach to enhance vaccine efficacy through nanocarrier systems. This review explores recent advances in nanocarrier-based vaccines for respiratory pathogens, focusing on their ability to promote mucosal immunity against viral infections. It examines various types of nanocarriers, their physicochemical properties, and their role in improving vaccine delivery and immune responses. Additionally, the review examines key findings from both preclinical and clinical studies, highlighting the progress and challenges in developing nanocarrier vaccines for respiratory infections. These insights underscore the potential of nanotechnology to transform vaccine strategies and address unmet needs in respiratory disease prevention.
AB - Respiratory infections continue to pose a major global health challenge, leading to high morbidity and mortality. Effective vaccines are crucial for prevention of these, and nanotechnology offers a promising approach to enhance vaccine efficacy through nanocarrier systems. This review explores recent advances in nanocarrier-based vaccines for respiratory pathogens, focusing on their ability to promote mucosal immunity against viral infections. It examines various types of nanocarriers, their physicochemical properties, and their role in improving vaccine delivery and immune responses. Additionally, the review examines key findings from both preclinical and clinical studies, highlighting the progress and challenges in developing nanocarrier vaccines for respiratory infections. These insights underscore the potential of nanotechnology to transform vaccine strategies and address unmet needs in respiratory disease prevention.
KW - disease X
KW - mucosal immunity
KW - nanocarrier vaccines
KW - respiratory pathogens
UR - http://www.scopus.com/inward/record.url?scp=85214005526&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2024.12.002
DO - 10.1016/j.molmed.2024.12.002
M3 - Review article
AN - SCOPUS:85214005526
SN - 1471-4914
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
ER -