TY - JOUR
T1 - Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo
AU - Zhang, Tian
AU - Yin, Han
AU - Li, Yu
AU - Yang, Haiyin
AU - Ge, Kun
AU - Zhang, Jinchao
AU - Yuan, Qing
AU - Dai, Xuyan
AU - Naeem, Abid
AU - Weng, Yuhua
AU - Huang, Yuanyu
AU - Liang, Xing Jie
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/6/21
Y1 - 2024/6/21
N2 - Nucleic acid therapeutics offer tremendous promise for addressing a wide range of common public health conditions. However, the in vivo nucleic acids delivery faces significant biological challenges. Lipid nanoparticles (LNPs) possess several advantages, such as simple preparation, high stability, efficient cellular uptake, endosome escape capabilities, etc., making them suitable for delivery vectors. However, the extensive hepatic accumulation of LNPs poses a challenge for successful development of LNPs-based nucleic acid therapeutics for extrahepatic diseases. To overcome this hurdle, researchers have been focusing on modifying the surface properties of LNPs to achieve precise delivery. The review aims to provide current insights into strategies for LNPs-based organ-selective nucleic acid delivery. In addition, it delves into the general design principles, targeting mechanisms, and clinical development of organ-selective LNPs. In conclusion, this review provides a comprehensive overview to provide guidance and valuable insights for further research and development of organ-selective nucleic acid delivery systems.
AB - Nucleic acid therapeutics offer tremendous promise for addressing a wide range of common public health conditions. However, the in vivo nucleic acids delivery faces significant biological challenges. Lipid nanoparticles (LNPs) possess several advantages, such as simple preparation, high stability, efficient cellular uptake, endosome escape capabilities, etc., making them suitable for delivery vectors. However, the extensive hepatic accumulation of LNPs poses a challenge for successful development of LNPs-based nucleic acid therapeutics for extrahepatic diseases. To overcome this hurdle, researchers have been focusing on modifying the surface properties of LNPs to achieve precise delivery. The review aims to provide current insights into strategies for LNPs-based organ-selective nucleic acid delivery. In addition, it delves into the general design principles, targeting mechanisms, and clinical development of organ-selective LNPs. In conclusion, this review provides a comprehensive overview to provide guidance and valuable insights for further research and development of organ-selective nucleic acid delivery systems.
KW - Drug delivery system
KW - Nanoparticles
KW - Nucleic acids
UR - http://www.scopus.com/inward/record.url?scp=85192478389&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.109804
DO - 10.1016/j.isci.2024.109804
M3 - Review article
AN - SCOPUS:85192478389
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 6
M1 - 109804
ER -
