Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Mengjie Zhang; Abid Hussain; Bo Hu; Haiyin Yang; Chunhui Li; Shuai Guo; Xiaofeng Han; Bei Li; Yunlu Dai; Yuhong Cao; Hang Chi; Yuhua Weng; Cheng Feng Qin; Yuanyu Huang

doi:10.1038/s41467-024-50752-9

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Mengjie Zhang, Abid Hussain, Bo Hu, Haiyin Yang, Chunhui Li, Shuai Guo, Xiaofeng Han, Bei Li, Yunlu Dai, Yuhong Cao, Hang Chi, Yuhua Weng, Cheng Feng Qin, Yuanyu Huang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

Original language	English
Article number	6463
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-50752-9
Publication status	Published - Dec 2024

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10.1038/s41467-024-50752-9

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title = "Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA",

abstract = "Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.",

author = "Mengjie Zhang and Abid Hussain and Bo Hu and Haiyin Yang and Chunhui Li and Shuai Guo and Xiaofeng Han and Bei Li and Yunlu Dai and Yuhong Cao and Hang Chi and Yuhua Weng and Qin, {Cheng Feng} and Yuanyu Huang",

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doi = "10.1038/s41467-024-50752-9",

language = "English",

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T1 - Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

AU - Zhang, Mengjie

AU - Hussain, Abid

AU - Hu, Bo

AU - Yang, Haiyin

AU - Li, Chunhui

AU - Guo, Shuai

AU - Han, Xiaofeng

AU - Li, Bei

AU - Dai, Yunlu

AU - Cao, Yuhong

AU - Chi, Hang

AU - Weng, Yuhua

AU - Qin, Cheng Feng

AU - Huang, Yuanyu

PY - 2024/12

Y1 - 2024/12

N2 - Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

AB - Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

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U2 - 10.1038/s41467-024-50752-9

DO - 10.1038/s41467-024-50752-9

M3 - Article

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AN - SCOPUS:85200299943

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 6463

ER -

Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA

Abstract

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