Abstract
A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.
| Original language | English |
|---|---|
| Pages (from-to) | 1082-1085 |
| Number of pages | 4 |
| Journal | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology |
| Volume | 32 |
| Issue number | 10 |
| Publication status | Published - Oct 2012 |
Keywords
- Analgesic medicine
- Carfentanil
- Synthesis