A new method for synthesizing carfentanil

Ke Jian Cui; Peng Wang; Zhi Bin Xu; Yan Qing Mi; Zi Hui Meng; Shu Shan Wang

A new method for synthesizing carfentanil

Ke Jian Cui, Peng Wang, Zhi Bin Xu, Yan Qing Mi, Zi Hui Meng^*, Shu Shan Wang

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.

源语言	英语
页（从-至）	1082-1085
页数	4
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	32
期	10
出版状态	已出版 - 10月 2012

其它文件与链接

链接到 Scopus 的出版物

引用此

Cui, K. J., Wang, P., Xu, Z. B., Mi, Y. Q., Meng, Z. H., & Wang, S. S. (2012). A new method for synthesizing carfentanil. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 32(10), 1082-1085.

@article{a68547e2e3f04415acfa815f01ab0c05,

title = "A new method for synthesizing carfentanil",

abstract = "A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.",

keywords = "Analgesic medicine, Carfentanil, Synthesis",

author = "Cui, {Ke Jian} and Peng Wang and Xu, {Zhi Bin} and Mi, {Yan Qing} and Meng, {Zi Hui} and Wang, {Shu Shan}",

year = "2012",

month = oct,

language = "English",

volume = "32",

pages = "1082--1085",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "10",

}

TY - JOUR

T1 - A new method for synthesizing carfentanil

AU - Cui, Ke Jian

AU - Wang, Peng

AU - Xu, Zhi Bin

AU - Mi, Yan Qing

AU - Meng, Zi Hui

AU - Wang, Shu Shan

PY - 2012/10

Y1 - 2012/10

N2 - A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.

AB - A novel method for synthesizing carfentanil is researched in this work. N-Boc-protected piperidinone was used as the starting material. The carfentanil was achieved via synthetic rout involving five steps: Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation. The overall yield of target compound was 31.6%. The structures of intermediates and final product were determined by infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrograph.

KW - Analgesic medicine

KW - Carfentanil

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=84871822292&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84871822292

SN - 1001-0645

VL - 32

SP - 1082

EP - 1085

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 10

ER -

A new method for synthesizing carfentanil

摘要

其它文件与链接

指纹

引用此