Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection

Xiaolu Xiong; Peng Zhu; Shanshan Li; Yujiu Jiang; Yurong Ma; Qingfan Shi; Xu Zhang; Xiaoming Shu; Zhiwei Wang; Linfeng Sun; Junfeng Han

doi:10.1007/s00604-022-05365-8

Electrochemical biosensor based on topological insulator Bi₂Se₃ tape electrode for HIV-1 DNA detection

Xiaolu Xiong, Peng Zhu, Shanshan Li, Yujiu Jiang, Yurong Ma, Qingfan Shi, Xu Zhang, Xiaoming Shu, Zhiwei Wang^*, Linfeng Sun^*, Junfeng Han^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A large-size Bi₂Se₃ tape electrode (BTE) was prepared by peeling off a 2 × 1 × 0.5 cm high-quality single crystal. The feasibility of using the flexible BTE as an efficient bioplatform to load Au nanoparticles and probe DNA for HIV-1 DNA electrochemical sensing was explored. Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) show that the resultant biosensor has a wide linear range from 0.1 fM to 1 pM, a low detection limit of 50 aM, excellent selectivity, reproducibility and stability, and is superior to the pM DNA detection level of Pt-Au, graphene-AuNPs hybrid biosensors. This outstanding performance is attributed to the intrinsic surface state of Bi₂Se₃ topological insulator in facilitating electron transfer. Therefore, BTE electrochemical biosensor platform has great potential in the application for sensitive detection of DNA biomarkers. Graphical abstract: [Figure not available: see fulltext.].

Original language	English
Article number	285
Journal	Microchimica Acta
Volume	189
Issue number	8
DOIs	https://doi.org/10.1007/s00604-022-05365-8
Publication status	Published - Aug 2022

Keywords

Au nanoparticles (AuNPs)
BiSe tape electrode (BTE)
Differential pulse voltammetry
Electrochemical biosensor
HIV-1 DNA
Topological insulator

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00604-022-05365-8

Cite this

@article{a7be9796bedf49b893000207ff7533ca,

title = "Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection",

abstract = "A large-size Bi2Se3 tape electrode (BTE) was prepared by peeling off a 2 × 1 × 0.5 cm high-quality single crystal. The feasibility of using the flexible BTE as an efficient bioplatform to load Au nanoparticles and probe DNA for HIV-1 DNA electrochemical sensing was explored. Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) show that the resultant biosensor has a wide linear range from 0.1 fM to 1 pM, a low detection limit of 50 aM, excellent selectivity, reproducibility and stability, and is superior to the pM DNA detection level of Pt-Au, graphene-AuNPs hybrid biosensors. This outstanding performance is attributed to the intrinsic surface state of Bi2Se3 topological insulator in facilitating electron transfer. Therefore, BTE electrochemical biosensor platform has great potential in the application for sensitive detection of DNA biomarkers. Graphical abstract: [Figure not available: see fulltext.].",

keywords = "Au nanoparticles (AuNPs), BiSe tape electrode (BTE), Differential pulse voltammetry, Electrochemical biosensor, HIV-1 DNA, Topological insulator",

author = "Xiaolu Xiong and Peng Zhu and Shanshan Li and Yujiu Jiang and Yurong Ma and Qingfan Shi and Xu Zhang and Xiaoming Shu and Zhiwei Wang and Linfeng Sun and Junfeng Han",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.",

year = "2022",

month = aug,

doi = "10.1007/s00604-022-05365-8",

language = "English",

volume = "189",

journal = "Microchimica Acta",

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T1 - Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection

AU - Xiong, Xiaolu

AU - Zhu, Peng

AU - Li, Shanshan

AU - Jiang, Yujiu

AU - Ma, Yurong

AU - Shi, Qingfan

AU - Zhang, Xu

AU - Shu, Xiaoming

AU - Wang, Zhiwei

AU - Sun, Linfeng

AU - Han, Junfeng

PY - 2022/8

Y1 - 2022/8

N2 - A large-size Bi2Se3 tape electrode (BTE) was prepared by peeling off a 2 × 1 × 0.5 cm high-quality single crystal. The feasibility of using the flexible BTE as an efficient bioplatform to load Au nanoparticles and probe DNA for HIV-1 DNA electrochemical sensing was explored. Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) show that the resultant biosensor has a wide linear range from 0.1 fM to 1 pM, a low detection limit of 50 aM, excellent selectivity, reproducibility and stability, and is superior to the pM DNA detection level of Pt-Au, graphene-AuNPs hybrid biosensors. This outstanding performance is attributed to the intrinsic surface state of Bi2Se3 topological insulator in facilitating electron transfer. Therefore, BTE electrochemical biosensor platform has great potential in the application for sensitive detection of DNA biomarkers. Graphical abstract: [Figure not available: see fulltext.].

AB - A large-size Bi2Se3 tape electrode (BTE) was prepared by peeling off a 2 × 1 × 0.5 cm high-quality single crystal. The feasibility of using the flexible BTE as an efficient bioplatform to load Au nanoparticles and probe DNA for HIV-1 DNA electrochemical sensing was explored. Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) show that the resultant biosensor has a wide linear range from 0.1 fM to 1 pM, a low detection limit of 50 aM, excellent selectivity, reproducibility and stability, and is superior to the pM DNA detection level of Pt-Au, graphene-AuNPs hybrid biosensors. This outstanding performance is attributed to the intrinsic surface state of Bi2Se3 topological insulator in facilitating electron transfer. Therefore, BTE electrochemical biosensor platform has great potential in the application for sensitive detection of DNA biomarkers. Graphical abstract: [Figure not available: see fulltext.].

KW - Au nanoparticles (AuNPs)

KW - BiSe tape electrode (BTE)

KW - Differential pulse voltammetry

KW - Electrochemical biosensor

KW - HIV-1 DNA

KW - Topological insulator

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