An improved correlation method based on rotation invariant feature for automatic particle selection

Yu Chen, Fei Ren, Xiaohua Wan, Xuan Wang, Fa Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Particle selection from cryo-electron microscopy (cryo-EM) images is very important for high-resolution reconstruction of macromolecular structure. However, the accuracy of existing selection methods are normally restricted to noise and low contrast of cryo-EM images. In this paper, we presented an improved correlation method based on rotation invariant features for automatic, fast particle selection. We first selected a preliminary particle set applying rotation invariant features, then filtered the preliminary particle set using correlation to reduce the interference of high noise background and improve the precision of correlation method. We used Divide and Conquer technique and cascade strategy to improve the recognition ability of features and reduce processing time. Experimental results on the benchmark of cryo-EM images show that our method can improve the accuracy of particle selection significantly.

Original languageEnglish
Title of host publicationBioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings
PublisherSpringer Verlag
Pages114-125
Number of pages12
ISBN (Print)9783319081700
DOIs
Publication statusPublished - 2014
Externally publishedYes
Event10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014 - Zhangjiajie, China
Duration: 28 Jun 201430 Jun 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8492 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014
Country/TerritoryChina
CityZhangjiajie
Period28/06/1430/06/14

Keywords

  • Cascade strategy
  • Correlation
  • Divide and Conquer
  • Particle selection
  • Rotation invariant feature

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