TY - JOUR
T1 - Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions
T2 - A Comprehensive Research Overview
AU - Kalsoom, Iqra
AU - Shehzadi, Kiran
AU - Li, Han Sheng
AU - Wen, Hong Liang
AU - Yu, Ming Jia
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
PY - 2024/6
Y1 - 2024/6
N2 - Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses. Graphical Abstract: (Figure presented.)
AB - Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses. Graphical Abstract: (Figure presented.)
KW - Cannabidiol
KW - Cannabinoid receptor
KW - Cannabis sativa
KW - Mechanism
KW - Structural activity relationship
UR - http://www.scopus.com/inward/record.url?scp=85194998500&partnerID=8YFLogxK
U2 - 10.1007/s41061-024-00465-w
DO - 10.1007/s41061-024-00465-w
M3 - Review article
C2 - 38829467
AN - SCOPUS:85194998500
SN - 2365-0869
VL - 382
JO - Topics in Current Chemistry
JF - Topics in Current Chemistry
IS - 2
M1 - 20
ER -