Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview

Iqra Kalsoom, Kiran Shehzadi, Han Sheng Li, Hong Liang Wen, Ming Jia Yu*

*此作品的通讯作者

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2 引用 (Scopus)

摘要

Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses. Graphical Abstract: (Figure presented.)

源语言英语
文章编号20
期刊Topics in Current Chemistry
382
2
DOI
出版状态已出版 - 6月 2024

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Kalsoom, I., Shehzadi, K., Li, H. S., Wen, H. L., & Yu, M. J. (2024). Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview. Topics in Current Chemistry, 382(2), 文章 20. https://doi.org/10.1007/s41061-024-00465-w