Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors

Bobin Wu; Yanchun Yang; Xiangyu Qin; Shuzhen Zhang; Chaojun Jing; Changjin Zhu; Bing Ma

doi:10.1002/cmdc.201300324

Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors

Bobin Wu, Yanchun Yang, Xiangyu Qin, Shuzhen Zhang, Chaojun Jing, Changjin Zhu^*, Bing Ma

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC₅₀ values in the low nanomolar to micromolar range.

Original language	English
Pages (from-to)	1913-1917
Number of pages	5
Journal	ChemMedChem
Volume	8
Issue number	12
DOIs	https://doi.org/10.1002/cmdc.201300324
Publication status	Published - Dec 2013

Keywords

aldehyde reductases
aldose reductases
diabetes complications
inhibitors
polyol pathway
quinoxalines
structure-activity relationships

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cmdc.201300324

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abstract = "ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC50 values in the low nanomolar to micromolar range.",

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AU - Qin, Xiangyu

AU - Zhang, Shuzhen

AU - Jing, Chaojun

AU - Zhu, Changjin

AU - Ma, Bing

PY - 2013/12

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KW - aldehyde reductases

KW - aldose reductases

KW - diabetes complications

KW - inhibitors

KW - polyol pathway

KW - quinoxalines

KW - structure-activity relationships

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ER -

Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors

Abstract

Keywords

UN SDGs

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