@article{2ffa814120994b73a47dc9100eadf6a4,
title = "Synthesis and structure-activity relationship studies of quinoxaline derivatives as aldose reductase inhibitors",
abstract = "ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC50 values in the low nanomolar to micromolar range.",
keywords = "aldehyde reductases, aldose reductases, diabetes complications, inhibitors, polyol pathway, quinoxalines, structure-activity relationships",
author = "Bobin Wu and Yanchun Yang and Xiangyu Qin and Shuzhen Zhang and Chaojun Jing and Changjin Zhu and Bing Ma",
year = "2013",
month = dec,
doi = "10.1002/cmdc.201300324",
language = "English",
volume = "8",
pages = "1913--1917",
journal = "ChemMedChem",
issn = "1860-7179",
publisher = "John Wiley and Sons Ltd",
number = "12",
}
