Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han; Weizhi Wang; Xiangqian Jia; Yixia Qian; Qian Li; Zihua Wang; Weikai Zhang; Shu Yang; Yunhong Jia; Zhiyuan Hu

doi:10.1021/acsami.6b05678

Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han, Weizhi Wang^*, Xiangqian Jia, Yixia Qian, Qian Li, Zihua Wang, Weikai Zhang, Shu Yang, Yunhong Jia, Zhiyuan Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

Original language	English
Pages (from-to)	18658-18663
Number of pages	6
Journal	ACS applied materials & interfaces
Volume	8
Issue number	29
DOIs	https://doi.org/10.1021/acsami.6b05678
Publication status	Published - 27 Jul 2016
Externally published	Yes

Keywords

VEGFR2
cancer therapy
drug delivery
pH-responsive peptide
switchable liposomes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsami.6b05678

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title = "Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery",

abstract = "One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be {"}turned on{"} and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.",

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author = "Qiuju Han and Weizhi Wang and Xiangqian Jia and Yixia Qian and Qian Li and Zihua Wang and Weikai Zhang and Shu Yang and Yunhong Jia and Zhiyuan Hu",

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year = "2016",

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doi = "10.1021/acsami.6b05678",

language = "English",

volume = "8",

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T2 - Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

AU - Han, Qiuju

AU - Wang, Weizhi

AU - Jia, Xiangqian

AU - Qian, Yixia

AU - Li, Qian

AU - Wang, Zihua

AU - Zhang, Weikai

AU - Yang, Shu

AU - Jia, Yunhong

AU - Hu, Zhiyuan

PY - 2016/7/27

Y1 - 2016/7/27

N2 - One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

AB - One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

KW - VEGFR2

KW - cancer therapy

KW - drug delivery

KW - pH-responsive peptide

KW - switchable liposomes

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M3 - Article

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SN - 1944-8244

VL - 8

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EP - 18663

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

IS - 29

ER -

Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Abstract

Keywords

UN SDGs

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