Research output per year
Research output per year
Personal profile
Personal profile
She is mainly engaged in the research of microfluidic chip screening and molecular recognition of highly selective peptides. National young talents, presided over the National Natural Science Foundation of China surface projects, the Central Military Commission after the Ministry of open research projects, Beijing Natural Science Foundation projects. She has published more than 50 papers in SCI journals as corresponding author, including Angew Chem Int Ed, Adv Mater, Chem Sci, ACS Nano, Anal Chem, Lab Chip, etc. Selected as Beijing Outstanding Talent Training youth top talent and Chinese Academy of Sciences Youth Promotion Association. She won the second prize of China Analytical and Testing Association Science and Technology (CAIA Award) as the first complete student. She is the director of Beijing Chromatographic Society. He is the young editorial board member of JOAT、Micro-Nano Lett、Chem Biomed Imaging and so on. More than 10 authorized invention patents, of which 1 has entered clinical (in vivo) application.
Research Interests
1. Targeted molecular recognition and precise chemical measurement
2. High Content screening analysis of microfluidic chips
3. Nanomedicine Detection based on polypeptide molecular probes
4. Biomolecular imaging and intelligent controllable biomedical materials
2. High Content screening analysis of microfluidic chips
3. Nanomedicine Detection based on polypeptide molecular probes
4. Biomolecular imaging and intelligent controllable biomedical materials
Education
2006.09-2011.07, PhD in Analytical Chemistry, Institute of Chemistry, Chinese Academy of Sciences;
2002.09-2006.06, Beijing Institute of Technology, Applied Chemistry, Bachelor of Science.
2002.09-2006.06, Beijing Institute of Technology, Applied Chemistry, Bachelor of Science.
Professional Experience
2023.8-present, Professor, Beijing Institute of Technology;
2019.07-2023.07, Beijing Institute of Technology, Special Researcher
2016.11-2017.12 Stanford University, Visiting Scholar
2011.08-2019.06, National NanoScience Center, Assistant Researcher, Associate Researcher
Research Achievement
1. Limin Zhang, Mengzhen Li, Minxuan Wang, Lingyun Li, Mingmei Guo, Yubin Ke, Peng Zhou, Weizhi Wang*. Tailored cross-β assemblies establish peptide “Dominos” structures for anchoring undruggable pharmacophores. Angew. Chem. Int. Ed. 2022, 61, e202212527.
2. Limin Zhang, Yuwei Tian, Mengzhen, Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang*. Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking. Chem. Sci. 2022, 13, 4052.
3. Limin Zhang, Zhenqi Jiang*, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu*, Minzhi Zhao*, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, Weizhi Wang*. Totipotent ‘all-in-one’ peptide sequentially blocks immune checkpoint and reverses immunosuppressive tumor microenvironment. Adv. Mater. 2022, e202207330.
4. Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang*, Bing Ma*, Weizhi Wang*. A “cell space station” for spatiotemporal molecular manipulation of immune checkpoint. ACS Nano 2022, 16, 16332.
5. Shang Wu, Limin Zhang, Weizhi Wang*. Screened αhelix peptide inhibitor toward SARS-CoV2 by blocking a Prion-like domain in the receptor binding domain. Anal. Chem. 2022, 94, 11464.
6. Mingmei Guo, Limin Zhang, Yuwei Tian, Minxuan Wang, and Weizhi Wang*. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics. Anal. Chem. 2021, 93, 8035.
7. Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, and Weizhi Wang*. Peptide-derived biosensors and their applications in tumor immunology related detection. Anal. Chem. 2022, 94, 431.
8. Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi Wang*. Synergetic tumor probes for facilitating therapeutic delivery by combined-functionalized peptide ligands. Anal. Chem. 2020, 92, 5650.
9. Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang*. Boosting the theranostic effect of liposomal probes toward prominin-1 through optimized dual-site targeting. Anal. Chem. 2019, 91, 7245.
10. Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao*, Weizhi Wang*. Controlled recognition and corona formation by cascade micellar nanoprobes: for boosting glioma theranostics. Anal. Chem. 2022, 94, 11118.
11. Yuwei Tian, Limin Zhang, Fangjie Liu, Minxuan Wang, Lingyun Li, Mingmei Guo, Hangyu Xu, Zhiying Yu, Weizhi Wang*. Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis. Biosens. Bioelectron. 2021, 184, 113235.
12. Mengzhen Li, Minxuan Wang, Lingyun Li, Limin Zhang, Bing Ma*, Weizhi Wang*. A composite peptide-supramolecular microneedle system for melanoma immunotherapy. Nano Res. 2022, e3032.
13. Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang*. Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring. Biomaterials 2019, 188, 96.
14. Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li, Yixia Qian, Chunyan Yue, Yuehua Wang, Linyang Fan, Yeteng Zhong, Ying Zhou, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu*, Yongye Liang*, Hongjie Dai*. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Adv. Mater. 2018, 30, 1800106.
15. Weizhi Wang*, Zhiyuan Hu*. Targeting peptide-based probes for molecular imaging and diagnosis. Adv. Mater. 2019, 31, 1804827.
2. Limin Zhang, Yuwei Tian, Mengzhen, Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang*. Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking. Chem. Sci. 2022, 13, 4052.
3. Limin Zhang, Zhenqi Jiang*, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu*, Minzhi Zhao*, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, Weizhi Wang*. Totipotent ‘all-in-one’ peptide sequentially blocks immune checkpoint and reverses immunosuppressive tumor microenvironment. Adv. Mater. 2022, e202207330.
4. Lingyun Li, Mengzhen Li, Minxuan Wang, Limin Zhang, Yao Yu, Jiatao Zhang*, Bing Ma*, Weizhi Wang*. A “cell space station” for spatiotemporal molecular manipulation of immune checkpoint. ACS Nano 2022, 16, 16332.
5. Shang Wu, Limin Zhang, Weizhi Wang*. Screened αhelix peptide inhibitor toward SARS-CoV2 by blocking a Prion-like domain in the receptor binding domain. Anal. Chem. 2022, 94, 11464.
6. Mingmei Guo, Limin Zhang, Yuwei Tian, Minxuan Wang, and Weizhi Wang*. Living-system-driven evolution of self-assembled-peptide probes: for boosting glioma theranostics. Anal. Chem. 2021, 93, 8035.
7. Minxuan Wang, Lingyun Li, Limin Zhang, Jinge Zhao, Zhenqi Jiang, and Weizhi Wang*. Peptide-derived biosensors and their applications in tumor immunology related detection. Anal. Chem. 2022, 94, 431.
8. Xiangqian Jia, Mingmei Guo, Qiuju Han, Yuwei Tian, Yafei Yuan, Zihua Wang, Yixia Qian, Weizhi Wang*. Synergetic tumor probes for facilitating therapeutic delivery by combined-functionalized peptide ligands. Anal. Chem. 2020, 92, 5650.
9. Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang*. Boosting the theranostic effect of liposomal probes toward prominin-1 through optimized dual-site targeting. Anal. Chem. 2019, 91, 7245.
10. Yao Yu, Minxuan Wang, Mengzhen Li, Limin Zhang, Jinge Zhao, Jie Cao*, Weizhi Wang*. Controlled recognition and corona formation by cascade micellar nanoprobes: for boosting glioma theranostics. Anal. Chem. 2022, 94, 11118.
11. Yuwei Tian, Limin Zhang, Fangjie Liu, Minxuan Wang, Lingyun Li, Mingmei Guo, Hangyu Xu, Zhiying Yu, Weizhi Wang*. Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis. Biosens. Bioelectron. 2021, 184, 113235.
12. Mengzhen Li, Minxuan Wang, Lingyun Li, Limin Zhang, Bing Ma*, Weizhi Wang*. A composite peptide-supramolecular microneedle system for melanoma immunotherapy. Nano Res. 2022, e3032.
13. Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang*. Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring. Biomaterials 2019, 188, 96.
14. Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li, Yixia Qian, Chunyan Yue, Yuehua Wang, Linyang Fan, Yeteng Zhong, Ying Zhou, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu*, Yongye Liang*, Hongjie Dai*. Molecular cancer imaging in the second near-infrared window using a renal-excreted NIR-II fluorophore-peptide probe. Adv. Mater. 2018, 30, 1800106.
15. Weizhi Wang*, Zhiyuan Hu*. Targeting peptide-based probes for molecular imaging and diagnosis. Adv. Mater. 2019, 31, 1804827.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Applications of peptide-based nanomaterials in targeting cancer therapy
Sun, B., Zhang, L., Li, M., Wang, X. & Wang, W., 2024, (Accepted/In press) In: Biomaterials Science.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Bioinspired Wearable Hydrogel Composite with Sustained Drug-Release for Wound Healing and Naked-Eye Visual Early Warning of Wound Dehiscence
Zheng, W., Muhammad, I., Yin, X., Fan, J., Murtaza, G., Zhang, N., Meng, Z., Wang, W. & Qiu, L., 18 Sept 2024, In: ACS Applied Materials and Interfaces. 16, 37, p. 49711-49723 13 p.Research output: Contribution to journal › Article › peer-review
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Construction of Targeting-Peptide-Based Imaging Reagents and Their Application in Bioimaging
Zhang, L., Wang, X., Zhao, J., Sun, B. & Wang, W., 22 Apr 2024, In: Chemical and Biomedical Imaging. 2, 4, p. 233-249 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Citations (Scopus) -
Hypoxia-triggered photothermal/drug combination therapy of tumors using a perylene diimide molecular capsule
Yang, F., Wang, G., Huang, K., Xu, Y., Feng, X., Wang, W. & Wei, W., 2024, (Accepted/In press) In: Science China Chemistry.Research output: Contribution to journal › Article › peer-review
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π-π Stacking Network-Based Supramolecular Peptide Nanoprobe for Visualization of the ICB-Enhanced Ferroptosis Process
Wang, X., Zhao, J., Zhang, J., Cao, J., Yu, Y., Ma, B., Niu, G., Lu, S., Zhang, L. & Wang, W., 13 Aug 2024, In: Analytical Chemistry. 96, 32, p. 13317-13325 9 p.Research output: Contribution to journal › Article › peer-review