Synthesis of functional organic dyes
Bioluminescence imaging Analysis
Disease Diagnosis and Treatment

2011.08-2016.07 PhD in Organic Chemistry, University of Chinese Academy of Sciences
2007.09-2011.07 Beijing Institute of Technology, Chemistry major, Bachelor of Science

2023.01-present Beijing Institute of Technology, Professor
2021.09-2022.08 Visiting Scholar, Dalian University of Technology
2020.01-2023.01 Professor, Shandong University
2016.11-2019.11 Postdoctoral Fellow, Hong Kong University of Science and Technology

Lifang Guo, Minggang Tian, Zhiyun Zhang, Qing Lu, Zhiqiang Liu, Guangle Niu*, Xiaoqiang Yu*. Simultaneous Two-Color Visualization of Lipid Droplets and Endoplasmic Reticulum and Their Interplay by Single Fluorescent Probes in Lambda Mode. J. Am. Chem. Soc. 2021, 143, 3169. (Supplementary Cover)
Guangle Niu, Xiuli Zheng, Zheng Zhao, Haoke Zhang, Jianguo Wang, Xuewen He, Yuncong Chen, Xiujuan Shi, Chao Ma, Ryan T. K. Kwok, Jacky W. Y. Lam, Herman H. Y. Sung, Ian D. Williams, Kam Sing Wong, Pengfei Wang, Ben Zhong Tang*. Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation, Efficient Red Emission and Two-Photon Bioimaging. J. Am. Chem. Soc. 2019, 141, 15111. (Supplementary Cover)
Tienan Zang, Yachen Xie, Sa Su, Feiran Liu, Qianqian Chen, Jing Jing, Rubo Zhang*, Guangle Niu*, Xiaoling Zhang*. In Vitro Light-Up Visualization of a Subunit-Specific Enzyme by an AIE Probe via Restriction of Single Molecular Motion. Angew. Chem. Int. Ed. 2020, 59, 10003.
Shixian Cao, Xiaoyuan Tian, Mingyue Cao, Jianguo Wang, Guangle Niu,* Ben Zhong Tang*. Solvatochromic Near-Infrared Aggregation-Induced Emission-Active Acrylonitriles by Acceptor Modulation for Low-Power Stimulated Emission Depletion Nanoscopy. Chem. Mater. 2023, DOI: 10.1021/acs.chemmater.2c03684.
Guangle Niu, Ruoyao Zhang, John P. C. Kwong, Jacky W. Y. Lam, Congping Chen, Jianguo Wang, Yuncong Chen, Xing Feng, Ryan T. K. Kwok, Herman H.-Y. Sung, Ian D. Williams, Mark R. J. Elsegood, Jianan Qu, Chao Ma, Kam Sing Wong, Xiaoqiang Yu*, Ben Zhong Tang*. Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration. Chem. Mater. 2018, 30, 4778.
Guangle Niu, Ruoyao Zhang, Yuan Gu, Jianguo Wang, Chao Ma, Ryan T. K. Kwok, Jacky W. Y. Lam, Herman H.-Y. Sung, Ian D. Williams, Kam Sing Wong, Xiaoqiang Yu, Ben Zhong Tang*. Highly photostable two-photon NIR AIEgens with tunable organelle specificity and deep tissue penetration. Biomaterials 2019, 208, 72.
Guangle Niu, Ruoyao Zhang, Xiujuan Shi, Hojeong Park, Sheng Xie, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang*. AIE luminogens as fluorescent bioprobes. TrAC Trend. Anal. Chem. 2020, 123, 115769
Mingyue Cao, Ting Zhu, Mengying Zhao, Fanda Meng, Zhiqiang Liu,* Jianguo Wang, Guangle Niu,* Xiaoqiang Yu. Structure Rigidification Promoted Ultrabright Solvatochromic Fluorescent Probes for Super-Resolution Imaging of Cytosolic and Nuclear Lipid Droplets. Anal. Chem. 2022, 94, 10676. (Supplementary Cover)
Cheng-Juan Wu,* Xin-Yu Li, Ting Zhu, Mengying Zhao, Zhuoyue Song, Shijie Li, Guo-Gang Shan, Guangle Niu*. Exploiting the Twisted Intramolecular Charge Transfer Effect to Construct a Wash-Free Solvatochromic Fluorescent Lipid Droplet Probe for Fatty Liver Disease Diagnosis. Anal. Chem. 2022, 94, 3881. (Supplementary Cover)
Li Huang, Deyan Qing, Shaojing Zhao, Xiaoli Wu, Ke Yang, Xiaojie Ren, Xiuli Zheng, Minhuan Lan*, Jun Ye*, Lintao Zeng*, Guangle Niu*. Acceptor-donor-acceptor structured deep-red AIE photosensitizer: Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy. Chem. Eng. J. 2022, 430, 132638.