Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han; Weizhi Wang; Xiangqian Jia; Yixia Qian; Qian Li; Zihua Wang; Weikai Zhang; Shu Yang; Yunhong Jia; Zhiyuan Hu

doi:10.1021/acsami.6b05678

Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han, Weizhi Wang^*, Xiangqian Jia, Yixia Qian, Qian Li, Zihua Wang, Weikai Zhang, Shu Yang, Yunhong Jia, Zhiyuan Hu

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

39 引用（Scopus）

摘要

One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

源语言	英语
页（从-至）	18658-18663
页数	6
期刊	ACS applied materials & interfaces
卷	8
期	29
DOI	https://doi.org/10.1021/acsami.6b05678
出版状态	已出版 - 27 7月 2016
已对外发布	是

联合国可持续发展目标

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10.1021/acsami.6b05678

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链接到 Scopus 的出版物

引用此

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title = "Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery",

abstract = "One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be {"}turned on{"} and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.",

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author = "Qiuju Han and Weizhi Wang and Xiangqian Jia and Yixia Qian and Qian Li and Zihua Wang and Weikai Zhang and Shu Yang and Yunhong Jia and Zhiyuan Hu",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = jul,

day = "27",

doi = "10.1021/acsami.6b05678",

language = "English",

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T1 - Switchable Liposomes

T2 - Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

AU - Han, Qiuju

AU - Wang, Weizhi

AU - Jia, Xiangqian

AU - Qian, Yixia

AU - Li, Qian

AU - Wang, Zihua

AU - Zhang, Weikai

AU - Yang, Shu

AU - Jia, Yunhong

AU - Hu, Zhiyuan

PY - 2016/7/27

Y1 - 2016/7/27

N2 - One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

AB - One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.

KW - VEGFR2

KW - cancer therapy

KW - drug delivery

KW - pH-responsive peptide

KW - switchable liposomes

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U2 - 10.1021/acsami.6b05678

DO - 10.1021/acsami.6b05678

M3 - Article

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AN - SCOPUS:84979738369

SN - 1944-8244

VL - 8

SP - 18658

EP - 18663

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

IS - 29

ER -

Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

摘要

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