Strategies for improving the production of bio-based vanillin

Ying Liu; Lichao Sun; Yi Xin Huo; Shuyuan Guo

doi:10.1186/s12934-023-02144-9

Strategies for improving the production of bio-based vanillin

Ying Liu, Lichao Sun^*, Yi Xin Huo, Shuyuan Guo^*

^*Corresponding author for this work

School of Life Science

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is one of the most popular flavors with wide applications in food, fragrance, and pharmaceutical industries. However, the high cost and limited yield of plant extraction failed to meet the vast market demand of natural vanillin. Vanillin biotechnology has emerged as a sustainable and cost-effective alternative to supply vanillin. In this review, we explored recent advances in vanillin biosynthesis and highlighted the potential of vanillin biotechnology. In particular, we addressed key challenges in using microorganisms and provided promising approaches for improving vanillin production with a special focus on chassis development, pathway construction and process optimization. Future directions of vanillin biosynthesis using inexpensive precursors are also thoroughly discussed.

Original language	English
Article number	147
Journal	Microbial Cell Factories
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12934-023-02144-9
Publication status	Published - Dec 2023

Keywords

Biosynthesis
Chassis development
Dynamic regulation
Pathway construction
Process optimization
Vanillin

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10.1186/s12934-023-02144-9

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title = "Strategies for improving the production of bio-based vanillin",

abstract = "Vanillin (4-hydroxy-3-methoxybenzaldehyde) is one of the most popular flavors with wide applications in food, fragrance, and pharmaceutical industries. However, the high cost and limited yield of plant extraction failed to meet the vast market demand of natural vanillin. Vanillin biotechnology has emerged as a sustainable and cost-effective alternative to supply vanillin. In this review, we explored recent advances in vanillin biosynthesis and highlighted the potential of vanillin biotechnology. In particular, we addressed key challenges in using microorganisms and provided promising approaches for improving vanillin production with a special focus on chassis development, pathway construction and process optimization. Future directions of vanillin biosynthesis using inexpensive precursors are also thoroughly discussed.",

keywords = "Biosynthesis, Chassis development, Dynamic regulation, Pathway construction, Process optimization, Vanillin",

author = "Ying Liu and Lichao Sun and Huo, {Yi Xin} and Shuyuan Guo",

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AU - Liu, Ying

AU - Sun, Lichao

AU - Huo, Yi Xin

AU - Guo, Shuyuan

PY - 2023/12

Y1 - 2023/12

N2 - Vanillin (4-hydroxy-3-methoxybenzaldehyde) is one of the most popular flavors with wide applications in food, fragrance, and pharmaceutical industries. However, the high cost and limited yield of plant extraction failed to meet the vast market demand of natural vanillin. Vanillin biotechnology has emerged as a sustainable and cost-effective alternative to supply vanillin. In this review, we explored recent advances in vanillin biosynthesis and highlighted the potential of vanillin biotechnology. In particular, we addressed key challenges in using microorganisms and provided promising approaches for improving vanillin production with a special focus on chassis development, pathway construction and process optimization. Future directions of vanillin biosynthesis using inexpensive precursors are also thoroughly discussed.

AB - Vanillin (4-hydroxy-3-methoxybenzaldehyde) is one of the most popular flavors with wide applications in food, fragrance, and pharmaceutical industries. However, the high cost and limited yield of plant extraction failed to meet the vast market demand of natural vanillin. Vanillin biotechnology has emerged as a sustainable and cost-effective alternative to supply vanillin. In this review, we explored recent advances in vanillin biosynthesis and highlighted the potential of vanillin biotechnology. In particular, we addressed key challenges in using microorganisms and provided promising approaches for improving vanillin production with a special focus on chassis development, pathway construction and process optimization. Future directions of vanillin biosynthesis using inexpensive precursors are also thoroughly discussed.

KW - Biosynthesis

KW - Chassis development

KW - Dynamic regulation

KW - Pathway construction

KW - Process optimization

KW - Vanillin

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DO - 10.1186/s12934-023-02144-9

M3 - Review article

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AN - SCOPUS:85166599146

SN - 1475-2859

VL - 22

JO - Microbial Cell Factories

JF - Microbial Cell Factories

IS - 1

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ER -

Strategies for improving the production of bio-based vanillin

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Keywords

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