Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations

Guopeng Tu; Ntirikwendera Deogratias; Meng Xu; Xiaowei Li; Jiajia Liu; Lan Jiang; Yanlian Yang; Jiatao Zhang

doi:10.1039/c8qm00185e

Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations

Guopeng Tu, Ntirikwendera Deogratias, Meng Xu^*, Xiaowei Li, Jiajia Liu, Lan Jiang, Yanlian Yang, Jiatao Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Sharp-featured Au@Ag core/shell nanocuboids were synthesized. Simulation and experimental results demonstrated that the sharp features and in-cuboid, out-of-cuboid LSPR coupling of the nanocuboids enabled high SERS activities. The ultrasensitive detection of single-point mutations of TDP-43 proteins was demonstrated at 10 pM for the first time. This could be a general strategy for single-point mutation detection in proteins.

Original language	English
Pages (from-to)	1720-1724
Number of pages	5
Journal	Materials Chemistry Frontiers
Volume	2
Issue number	9
DOIs	https://doi.org/10.1039/c8qm00185e
Publication status	Published - Sept 2018

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abstract = "Sharp-featured Au@Ag core/shell nanocuboids were synthesized. Simulation and experimental results demonstrated that the sharp features and in-cuboid, out-of-cuboid LSPR coupling of the nanocuboids enabled high SERS activities. The ultrasensitive detection of single-point mutations of TDP-43 proteins was demonstrated at 10 pM for the first time. This could be a general strategy for single-point mutation detection in proteins.",

author = "Guopeng Tu and Ntirikwendera Deogratias and Meng Xu and Xiaowei Li and Jiajia Liu and Lan Jiang and Yanlian Yang and Jiatao Zhang",

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AU - Tu, Guopeng

AU - Deogratias, Ntirikwendera

AU - Xu, Meng

AU - Li, Xiaowei

AU - Liu, Jiajia

AU - Jiang, Lan

AU - Yang, Yanlian

AU - Zhang, Jiatao

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N2 - Sharp-featured Au@Ag core/shell nanocuboids were synthesized. Simulation and experimental results demonstrated that the sharp features and in-cuboid, out-of-cuboid LSPR coupling of the nanocuboids enabled high SERS activities. The ultrasensitive detection of single-point mutations of TDP-43 proteins was demonstrated at 10 pM for the first time. This could be a general strategy for single-point mutation detection in proteins.

AB - Sharp-featured Au@Ag core/shell nanocuboids were synthesized. Simulation and experimental results demonstrated that the sharp features and in-cuboid, out-of-cuboid LSPR coupling of the nanocuboids enabled high SERS activities. The ultrasensitive detection of single-point mutations of TDP-43 proteins was demonstrated at 10 pM for the first time. This could be a general strategy for single-point mutation detection in proteins.

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Sharp-featured Au@Ag core/shell nanocuboid synthesis and the label-free ultrasensitive SERS detection of protein single-point mutations

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