Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

Xiangqian Jia; Weizhi Wang; Qiuju Han; Zihua Wang; Yunhong Jia; Zhiyuan Hu

doi:10.1021/acsmedchemlett.6b00028

Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

Xiangqian Jia, Weizhi Wang^*, Qiuju Han, Zihua Wang, Yunhong Jia, Zhiyuan Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.

Original language	English
Pages (from-to)	429-434
Number of pages	6
Journal	ACS Medicinal Chemistry Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/acsmedchemlett.6b00028
Publication status	Published - 14 Apr 2016
Externally published	Yes

Keywords

Antitumor
HER2
Nanocarrier
YLFFVFER

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsmedchemlett.6b00028

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title = "Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery",

abstract = "We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.",

keywords = "Antitumor, HER2, Nanocarrier, YLFFVFER",

author = "Xiangqian Jia and Weizhi Wang and Qiuju Han and Zihua Wang and Yunhong Jia and Zhiyuan Hu",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

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doi = "10.1021/acsmedchemlett.6b00028",

language = "English",

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journal = "ACS Medicinal Chemistry Letters",

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T1 - Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

AU - Jia, Xiangqian

AU - Wang, Weizhi

AU - Han, Qiuju

AU - Wang, Zihua

AU - Jia, Yunhong

AU - Hu, Zhiyuan

PY - 2016/4/14

Y1 - 2016/4/14

N2 - We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.

AB - We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.

KW - Antitumor

KW - HER2

KW - Nanocarrier

KW - YLFFVFER

UR - http://www.scopus.com/inward/record.url?scp=84965031178&partnerID=8YFLogxK

U2 - 10.1021/acsmedchemlett.6b00028

DO - 10.1021/acsmedchemlett.6b00028

M3 - Article

AN - SCOPUS:84965031178

SN - 1948-5875

VL - 7

SP - 429

EP - 434

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 4

ER -

Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

Abstract

Keywords

UN SDGs

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