@inproceedings{383b783b2e014ed2a633d4ce2c8ceae7,
title = "Late-stage peptide modification via aspartic acid as endogenous directing group",
abstract = "Polypeptide drugs have become one of the most crucial tools in drug research and other related fields because of their high pharmacological activity, low dosage, low toxicity and side effects. However, the problems of poor metabolic stability, short half-value period and difficulty in penetration have greatly limit the development of new polypeptide drugs rendering the functional modification of peptides a crucial tool to polypeptide drugs. In this paper, we developed a new strategy for peptide functionalization through the usage of aspartic acid side chain as an endogenous directing group to realize polypeptide's selective bond arylation.",
keywords = "functionalization, peptide, Polypeptide drug, position selectivity",
author = "Mengjie Liao and Bo Yao",
note = "Publisher Copyright: {\textcopyright} 2023 IOS Press. All rights reserved.; 3rd International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2023 ; Conference date: 16-06-2023 Through 18-06-2023",
year = "2023",
month = nov,
day = "23",
doi = "10.3233/SHTI230825",
language = "English",
series = "Studies in Health Technology and Informatics",
publisher = "IOS Press BV",
pages = "62--67",
editor = "Yitao Yu and Nguyen, {Binh P.} and Jun Sang",
booktitle = "Advances in Biomedical and Bioinformatics Engineering - Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2023",
address = "Netherlands",
}