He received his bachelor's degree in Chemistry from the University of Science and Technology of China (Supervisor: Professor Wang Zhiyong) in 2005. He received his Doctor of Science degree in Chemistry from the Institute of Chemistry, Chinese Academy of Sciences (Supervisor: Academician Wang Meixiang) in 2010. He worked as a postdoctoral researcher at the Ecole Polytechnique Federal de Lausanne, Switzerland (Supervisor: Professor Jieping Zhu has been working at the School of Chemistry and Chemical Engineering, Beijing Institute of Technology since 2015. He has carried out research in supramolecular macrocyclic chemistry, high-priced organic copper chemistry, transition metal catalytic synthesis methodology and other fields, and undertook projects of the National Natural Science Foundation, major cultivation projects of Beijing Institute of Technology and enterprise horizontal projects. He teaches organic chemistry, advanced organic chemistry, organic chemistry experiment and other undergraduate courses.

Current research interests include: 1) liquid/solid phase synthesis of polypeptides, selective chemical modification and its application; 2) New activation strategies for C-H, C-Si and C-F bonds; 3) The synthesis of high-priced organic copper compounds and their applications in the modification of biological macromolecules such as peptides, proteins and nucleic acids.

2005-2010 Doctor of Science, Institute of Chemistry, Chinese Academy of Sciences
2001-2005 Bachelor of Science, Chemistry, University of Science and Technology of China

2015-present Researcher, School of Chemistry and Chemical Engineering, Beijing Institute of Technology
2010-2014 Postdoc, Ecole Polytechnique Federale de Lausanne, Switzerland

(1) Selective C-H bond functionalization of polypeptide adipose chain (2019 to date) : In recent years, polypeptide therapeutics have received widespread attention, and more and more polypeptide drugs have been marketed or entered clinical research. Through the site-selective post-modification of polypeptides, non-natural amino acids can be introduced into specific positions of polypeptides, which can not only effectively improve their physical and chemical properties, but also introduce more new functions. We have developed a series of coordination strategies using transition metal catalysis to achieve selective functional group of the inert sp3 C-H bond of the polypeptide side chain. The relevant results were published in Org.Lett.(4 articles).
(2) amino-guided C-H bond functionalization (2018-2020) : Due to the strong coordination donor properties, alkalinity and reducibility of amino group, its direct use as a guide group for transition metal-catalyzed C-H bond functionalization is a big challenge. By adjusting the acidity of the reaction system and the additives, we have successively realized the remote sp3 carbo-hydrogen arylation of fatty amines, amino acids and their derivatives catalyzed by primary amine. The relevant results were published in Org.Lett.(1 article), J.Org.Chem.(1 article), Chin.Chem.Lett.(1 article).
(3) New coupling reaction design (2012-2018) : Based on the amine palladiation reaction of alkynes, a green and efficient catalytic system [Pd(II)/TBAI/AcOH/DMSO/O2] was established. A series of simple and easily obtained alkynes were efficiently converted into potential bioactive heterocycle compounds by means of a cyclic coupling reaction strategy. The action mechanism of anions in each elementary reaction and the effect on the active catalytic species were revealed, and finally a green catalytic method with low catalyst loading was developed. In addition, the catalytic system of palladium and silver bimetal [Pd(II)/Ag(I)/additives] was developed using the simple and easily obtained allyl trimethylsilane as coupling reagent, and the high efficiency and selectivity of allyl silane cross-coupling reaction with aryl iodide and aryl boric acid was realized under the conditions of ligand-free and fluorine-free, respectively. Relevant results were published in Angew.Chem.(3 papers), Org.Lett.(2 papers), Chem.Eur.J.(3 papers), etc.
(4) Hypervalent organic copper Chemistry (2006-2014) : A class of organic trivalent copper compounds with novel structure and stability at room temperature were prepared by using nitrogen atom-bridging cupric [3] pyridine [1] aromatics as ligands. The reaction properties of these hypervalent copper compounds with anionic nucleophiles were first discovered and reported. By systematically studying the structure, reaction properties and formation mechanism of organic trivalent copper, the unique structure and reaction properties of trivalent copper were demonstrated, which filled up the lack of understanding of high price copper. On this basis, we designed and developed a direct functionalization reaction of C-H bond catalyzed by copper at room temperature, which provides a new idea for studying the mechanism of organic reaction catalyzed by copper and new reaction design. Relevant results have been published in JACS(1 paper), Chem.Commun.(1 paper), and J.Org.Chem.(3 papers).