摘要
Polypeptide drugs have become one of the most crucial tools in drug research and other related fields because of their high pharmacological activity, low dosage, low toxicity and side effects. However, the problems of poor metabolic stability, short half-value period and difficulty in penetration have greatly limit the development of new polypeptide drugs rendering the functional modification of peptides a crucial tool to polypeptide drugs. In this paper, we developed a new strategy for peptide functionalization through the usage of aspartic acid side chain as an endogenous directing group to realize polypeptide's selective bond arylation.
| 源语言 | 英语 |
|---|---|
| 主期刊名 | Advances in Biomedical and Bioinformatics Engineering - Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2023 |
| 编辑 | Yitao Yu, Binh P. Nguyen, Jun Sang |
| 出版商 | IOS Press BV |
| 页 | 62-67 |
| 页数 | 6 |
| ISBN（电子版） | 9781643684321 |
| DOI | |
| 出版状态 | 已出版 - 23 11月 2023 |
| 活动 | 3rd International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2023 - Hybrid, Nanjing, 中国 期限: 16 6月 2023 → 18 6月 2023 |
出版系列
| 姓名 | Studies in Health Technology and Informatics |
|---|---|
| 卷 | 308 |
| ISSN（印刷版） | 0926-9630 |
| ISSN（电子版） | 1879-8365 |
会议
| 会议 | 3rd International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2023 |
|---|---|
| 国家/地区 | 中国 |
| 市 | Hybrid, Nanjing |
| 时期 | 16/06/23 → 18/06/23 |
指纹
探究 'Late-stage peptide modification via aspartic acid as endogenous directing group' 的科研主题。它们共同构成独一无二的指纹。引用此
Liao, M., & Yao, B. (2023). Late-stage peptide modification via aspartic acid as endogenous directing group. 在 Y. Yu, B. P. Nguyen, & J. Sang (编辑), Advances in Biomedical and Bioinformatics Engineering - Proceedings of the 3rd International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2023 (页码 62-67). (Studies in Health Technology and Informatics; 卷 308). IOS Press BV. https://doi.org/10.3233/SHTI230825