Xiaoyan Ma

Ma Xiaoyan, Special Associate Researcher, Doctoral Supervisor
Office: A204, Linjian Building, Zhongguancun Campus (opposite the main entrance of the library)
Email: xyma@bit.edu.cn

, Special Associate Researcher, Doctoral Supervisor
Office: A204, Linjian Building, Zhongguancun Campus (opposite the main entrance of the library)
Email: xyma@bit.edu.cn
Educational Background:
2011-2016, Nanjing Institute of Soil Science, Chinese Academy of Sciences, PhD
2007-2011, Northwest A&F University, B.S.
Work Experience:
2018-present, Special Associate Researcher, School of Life Sciences, Beijing Institute of Technology
2016-2018, Postdoctoral Fellow, School of Life Sciences, Beijing Institute of Technology
Academic Part-time:
Member of the Working Committee of Young Scholars in Biochemistry
Research Direction:
Developing biosynthetic pathways for high-value chemicals, new functional components, high-version chassis and efficient microbial cell factories for synthetic biology and green biofabration. The first rare codon-based amino acid high-yield strain screening system was established, which solved the problems of high error rate and low positive rate faced by traditional analogue screening methods. Multiple functional modules including growth independent driving elements, synthetic pathway diversion elements, expression intensity regulatory elements, and total metabolic resource control valves were constructed, and the metabolic flow distribution mode of natural strains was reconstructed. Robust production of high value-added chemicals is achieved. The research results have been published in high-level journals such as Nat Commun, a nature sub-journal, and the research directions include but are not limited to: (1) Enabling technology: high-throughput screening technology and gene editing technology
(2) Functional components: Artificial design of enzyme proteins, unnatural proteins and nucleic acid components
(3) Chassis cells: Transcriptional regulation, metabolic flow redirection, robust cell factory
(4) Target products: Biosynthesis of amino acids, biofuels, drug precursors
(5) Artificial community: Regulation and reconstruction of intestinal flora
Research Project:
(1) National Natural Science Foundation of China, Screening and strain reconstruction of amino acid high-yielding strains based on codon expansion, 2021.01-2023.12, Director, 240,000
(2) National Key Research and Development Program, Construction and Application of Synthetic Intestinal flora System for Neurodegenerative diseases, 2020.01-2024.12, Sub-project leader, 1.45 million
(3) Major Research Program of National Natural Science Foundation of China, Diversity of Energy Coupling Reaction of anaerobic sulfur Oxidation and its relationship with other element cycles, 2020.01-2022.12, Project Leader, 250,000
(4) "20 Universities" project, Microbial high-value transformation of fermentation waste, 2020.01-2022.12, backbone, 300,000
(5) Zhenjiang Key Research and Development Project, Research and development of engineering bacteria mixed microbial preparations for Efficient utilization of feed nutrition, 20221.06-2023.05, backbone, 550,000
(6) "Academic Start-up Program for Young Teachers", Beijing Institute of Technology, Research on Improving the robustness of microbial cell factories under stress conditions by modifying RNA polymerase, 2020/01-2022/12,400,000, ongoing research, host
(7) China Postdoctoral Research Foundation, Research on Feedback Inhibition and Disinhibition of CO2 Fixation Pathway in facultative autotrophic Microorganisms, 2017/11-2019/10, 50,000 yuan, Chair
Patent:
(1) Huo Yixin,
, Special Associate Researcher, Doctoral Supervisor
Office: A204, Linjian Building, Zhongguancun Campus (opposite the main entrance of the library)
Email: xyma@bit.edu.cn
Educational Background:
2011-2016, Nanjing Institute of Soil Science, Chinese Academy of Sciences, PhD
2007-2011, Northwest A&F University, B.S.
Work Experience:
2018-present, Special Associate Researcher, School of Life Sciences, Beijing Institute of Technology
2016-2018, Postdoctoral Fellow, School of Life Sciences, Beijing Institute of Technology
Academic Part-time:
Member of the Working Committee of Young Scholars in Biochemistry
Research Direction:
Developing biosynthetic pathways for high-value chemicals, new functional components, high-version chassis and efficient microbial cell factories for synthetic biology and green biofabration. The first rare codon-based amino acid high-yield strain screening system was established, which solved the problems of high error rate and low positive rate faced by traditional analogue screening methods. Multiple functional modules including growth independent driving elements, synthetic pathway diversion elements, expression intensity regulatory elements, and total metabolic resource control valves were constructed, and the metabolic flow distribution mode of natural strains was reconstructed. Robust production of high value-added chemicals is achieved. The research results have been published in high-level journals such as Nat Commun, a nature sub-journal, and the research directions include but are not limited to: (1) Enabling technology: high-throughput screening technology and gene editing technology
(2) Functional components: Artificial design of enzyme proteins, unnatural proteins and nucleic acid components
(3) Chassis cells: Transcriptional regulation, metabolic flow redirection, robust cell factory
(4) Target products: Biosynthesis of amino acids, biofuels, drug precursors
(5) Artificial community: Regulation and reconstruction of intestinal flora
Research Project:
(1) National Natural Science Foundation of China, Screening and strain reconstruction of amino acid high-yielding strains based on codon expansion, 2021.01-2023.12, Director, 240,000
(2) National Key Research and Development Program, Construction and Application of Synthetic Intestinal flora System for Neurodegenerative diseases, 2020.01-2024.12, Sub-project leader, 1.45 million
(3) Major Research Program of National Natural Science Foundation of China, Diversity of Energy Coupling Reaction of anaerobic sulfur Oxidation and its relationship with other element cycles, 2020.01-2022.12, Project Leader, 250,000
(4) "20 Universities" project, Microbial high-value transformation of fermentation waste, 2020.01-2022.12, backbone, 300,000
(5) Zhenjiang Key Research and Development Project, Research and development of engineering bacteria mixed microbial preparations for Efficient utilization of feed nutrition, 20221.06-2023.05, backbone, 550,000
(6) "Academic Start-up Program for Young Teachers", Beijing Institute of Technology, Research on Improving the robustness of microbial cell factories under stress conditions by modifying RNA polymerase, 2020/01-2022/12,400,000, ongoing research, host
(7) China Postdoctoral Research Foundation, Research on Feedback Inhibition and Disinhibition of CO2 Fixation Pathway in facultative autotrophic Microorganisms, 2017/11-2019/10, 50,000 yuan, Chair
Patent:
(1) Huo Yixin,

Developing biosynthetic pathways for high-value chemicals, new functional components, high-version chassis and efficient microbial cell factories for synthetic biology and green biofabration. The first rare codon-based amino acid high-yield strain screening system was established, which solved the problems of high error rate and low positive rate faced by traditional analogue screening methods. Multiple functional modules including growth independent driving elements, synthetic pathway diversion elements, expression intensity regulatory elements, and total metabolic resource control valves were constructed, and the metabolic flow distribution mode of natural strains was reconstructed. Robust production of high value-added chemicals is achieved. The research results have been published in high-level journals such as Nat Commun, a nature sub-journal, and the research directions include but are not limited to: (1) Enabling technology: high-throughput screening technology and gene editing technology
(2) Functional components: Artificial design of enzyme proteins, unnatural proteins and nucleic acid components
(3) Chassis cells: Transcriptional regulation, metabolic flow redirection, robust cell factory
(4) Target products: Biosynthesis of amino acids, biofuels, drug precursors
(5) Artificial community: Regulation and reconstruction of intestinal flora


Developing biosynthetic pathways for high-value chemicals, new functional components, high-version chassis and efficient microbial cell factories for synthetic biology and green biofabration. The first rare codon-based amino acid high-yield strain screening system was established, which solved the problems of high error rate and low positive rate faced by traditional analogue screening methods. Multiple functional modules including growth independent driving elements, synthetic pathway diversion elements, expression intensity regulatory elements, and total metabolic resource control valves were constructed, and the metabolic flow distribution mode of natural strains was reconstructed. Robust production of high value-added chemicals is achieved. The research results have been published in high-level journals such as Nat Commun, a nature sub-journal, and the research directions include but are not limited to: (1) Enabling technology: high-throughput screening technology and gene editing technology
(2) Functional components: Artificial design of enzyme proteins, unnatural proteins and nucleic acid components
(3) Chassis cells: Transcriptional regulation, metabolic flow redirection, robust cell factory
(4) Target products: Biosynthesis of amino acids, biofuels, drug precursors
(5) Artificial community: Regulation and reconstruction of intestinal flora

2011-2016, Nanjing Institute of Soil Science, Chinese Academy of Sciences, PhD
2007-2011, Northwest A&F University, B.S.

2018-present, Special Associate Researcher, School of Life Sciences, Beijing Institute of Technology
2016-2018, Postdoctoral Fellow, School of Life Sciences, Beijing Institute of Technology


2018-present, Special Associate Researcher, School of Life Sciences, Beijing Institute of Technology
2016-2018, Postdoctoral Fellow, School of Life Sciences, Beijing Institute of Technology

(1) National Natural Science Foundation of China, Screening and strain reconstruction of amino acid high-yielding strains based on codon expansion, 2021.01-2023.12, Director, 240,000
(2) National Key Research and Development Program, Construction and Application of Synthetic Intestinal flora System for Neurodegenerative diseases, 2020.01-2024.12, Sub-project leader, 1.45 million
(3) Major Research Program of National Natural Science Foundation of China, Diversity of Energy Coupling Reaction of anaerobic sulfur Oxidation and its relationship with other element cycles, 2020.01-2022.12, Project Leader, 250,000
(4) "20 Universities" project, Microbial high-value transformation of fermentation waste, 2020.01-2022.12, backbone, 300,000
(5) Zhenjiang Key Research and Development Project, Research and development of engineering bacteria mixed microbial preparations for Efficient utilization of feed nutrition, 20221.06-2023.05, backbone, 550,000
(6) "Academic Start-up Program for Young Teachers", Beijing Institute of Technology, Research on Improving the robustness of microbial cell factories under stress conditions by modifying RNA polymerase, 2020/01-2022/12,400,000, ongoing research, host
(7) China Postdoctoral Research Foundation, Research on Feedback Inhibition and Disinhibition of CO2 Fixation Pathway in facultative autotrophic Microorganisms, 2017/11-2019/10, 50,000 yuan, Chair