Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen; Zhi Feng Zhang; Ning Ning Liu; Yu Hong Xiang; Zhuo Yong Zhang; Graciela Andrei; Robert Snoeck; Dominique Schols; Qing Shan Zhang; Qin Pei Wu

doi:10.1080/15257770.2015.1115523

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen, Zhi Feng Zhang, Ning Ning Liu, Yu Hong Xiang, Zhuo Yong Zhang, Graciela Andrei, Robert Snoeck, Dominique Schols, Qing Shan Zhang, Qin Pei Wu^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

Original language	English
Pages (from-to)	147-160
Number of pages	14
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	35
Issue number	3
DOIs	https://doi.org/10.1080/15257770.2015.1115523
Publication status	Published - 3 Mar 2016

Keywords

Huisgen 1,3,g-dipolar cycloaddition
antiviral
nucleosides
triazole

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10.1080/15257770.2015.1115523

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title = "Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides",

abstract = "A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.",

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T1 - Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

AU - Wen, Yi Ning

AU - Zhang, Zhi Feng

AU - Liu, Ning Ning

AU - Xiang, Yu Hong

AU - Zhang, Zhuo Yong

AU - Andrei, Graciela

AU - Snoeck, Robert

AU - Schols, Dominique

AU - Zhang, Qing Shan

AU - Wu, Qin Pei

PY - 2016/3/3

Y1 - 2016/3/3

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AB - A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

KW - Huisgen 1,3,g-dipolar cycloaddition

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KW - nucleosides

KW - triazole

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DO - 10.1080/15257770.2015.1115523

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JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 3

ER -

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

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Keywords

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