Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen; Zhi Feng Zhang; Ning Ning Liu; Yu Hong Xiang; Zhuo Yong Zhang; Graciela Andrei; Robert Snoeck; Dominique Schols; Qing Shan Zhang; Qin Pei Wu

doi:10.1080/15257770.2015.1115523

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen, Zhi Feng Zhang, Ning Ning Liu, Yu Hong Xiang, Zhuo Yong Zhang, Graciela Andrei, Robert Snoeck, Dominique Schols, Qing Shan Zhang, Qin Pei Wu^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

Original language	English
Pages (from-to)	147-160
Number of pages	14
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	35
Issue number	3
DOIs	https://doi.org/10.1080/15257770.2015.1115523
Publication status	Published - 3 Mar 2016

Keywords

Huisgen 1,3,g-dipolar cycloaddition
antiviral
nucleosides
triazole

Access to Document

10.1080/15257770.2015.1115523

Cite this

Wen, Y. N., Zhang, Z. F., Liu, N. N., Xiang, Y. H., Zhang, Z. Y., Andrei, G., Snoeck, R., Schols, D., Zhang, Q. S., & Wu, Q. P. (2016). Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides. Nucleosides, Nucleotides and Nucleic Acids, 35(3), 147-160. https://doi.org/10.1080/15257770.2015.1115523

@article{1f2cc99a9f24405cbac7f74146a5dac7,

title = "Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides",

abstract = "A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.",

keywords = "Huisgen 1,3,g-dipolar cycloaddition, antiviral, nucleosides, triazole",

author = "Wen, {Yi Ning} and Zhang, {Zhi Feng} and Liu, {Ning Ning} and Xiang, {Yu Hong} and Zhang, {Zhuo Yong} and Graciela Andrei and Robert Snoeck and Dominique Schols and Zhang, {Qing Shan} and Wu, {Qin Pei}",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor & Francis Group, LLC.",

year = "2016",

month = mar,

day = "3",

doi = "10.1080/15257770.2015.1115523",

language = "English",

volume = "35",

pages = "147--160",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

AU - Wen, Yi Ning

AU - Zhang, Zhi Feng

AU - Liu, Ning Ning

AU - Xiang, Yu Hong

AU - Zhang, Zhuo Yong

AU - Andrei, Graciela

AU - Snoeck, Robert

AU - Schols, Dominique

AU - Zhang, Qing Shan

AU - Wu, Qin Pei

PY - 2016/3/3

Y1 - 2016/3/3

N2 - A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

AB - A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

KW - Huisgen 1,3,g-dipolar cycloaddition

KW - antiviral

KW - nucleosides

KW - triazole

UR - http://www.scopus.com/inward/record.url?scp=84960465171&partnerID=8YFLogxK

U2 - 10.1080/15257770.2015.1115523

DO - 10.1080/15257770.2015.1115523

M3 - Article

C2 - 26854981

AN - SCOPUS:84960465171

SN - 1525-7770

VL - 35

SP - 147

EP - 160

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 3

ER -

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this