Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

Yi Ning Wen, Zhi Feng Zhang, Ning Ning Liu, Yu Hong Xiang, Zhuo Yong Zhang, Graciela Andrei, Robert Snoeck, Dominique Schols, Qing Shan Zhang, Qin Pei Wu*

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

9 引用 (Scopus)

摘要

A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.

源语言英语
页(从-至)147-160
页数14
期刊Nucleosides, Nucleotides and Nucleic Acids
35
3
DOI
出版状态已出版 - 3 3月 2016

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