Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

Li Li Tan; Haiwei Li; Yu Chen Qiu; Dai Xiong Chen; Xin Wang; Rui Yi Pan; Yan Wang; Sean Xiao An Zhang; Bo Wang; Ying Wei Yang

doi:10.1039/c4sc03749a

Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

Li Li Tan, Haiwei Li, Yu Chen Qiu, Dai Xiong Chen, Xin Wang, Rui Yi Pan, Yan Wang, Sean Xiao An Zhang, Bo Wang^*, Ying Wei Yang

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

206 Citations (Scopus)

Abstract

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

Original language	English
Pages (from-to)	1640-1644
Number of pages	5
Journal	Chemical Science
Volume	6
Issue number	3
DOIs	https://doi.org/10.1039/c4sc03749a
Publication status	Published - 1 Mar 2015

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title = "Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches",

abstract = "Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.",

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T1 - Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

AU - Tan, Li Li

AU - Li, Haiwei

AU - Qiu, Yu Chen

AU - Chen, Dai Xiong

AU - Wang, Xin

AU - Pan, Rui Yi

AU - Wang, Yan

AU - Zhang, Sean Xiao An

AU - Wang, Bo

AU - Yang, Ying Wei

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Y1 - 2015/3/1

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Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches

Abstract

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