Ru(II) polypyridyl complex-incorporated and folate-conjugated vehicle for cancer cell imaging and photoinduced inactivation

Li Li Huang; Jin Xu; Yong Jie Jin; Dong Xu Zhao; Hai Yan Xie

doi:10.1039/c5an02650d

Ru(II) polypyridyl complex-incorporated and folate-conjugated vehicle for cancer cell imaging and photoinduced inactivation

Li Li Huang, Jin Xu, Yong Jie Jin, Dong Xu Zhao, Hai Yan Xie^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Ru(ii) polypyridyl complexes have been expected as promising therapeutic agents against cancer owing to its DNA photocleavage activity. However, the lack of cell selectivity poses a significant obstacle to their practical application. Herein, the strategy combining cell-specific imaging with photoinduced cell death based on [Ru(phen)₂(dppz)]²⁺ has been developed by incorporating [Ru(phen)₂(dppz)]²⁺ into folate-conjugated liposomes. The cells overexpressing folate receptors could specifically recognize this vehicle and be imaged through the luminescence of [Ru(phen)₂(dppz)]²⁺. Thereafter, the delivered [Ru(phen)₂(dppz)]²⁺ interacted with DNA in cells and led to photoinduced cell death. This work provided a possible alternative for cancer diagnosis and therapy.

Original language	English
Pages (from-to)	2948-2954
Number of pages	7
Journal	The Analyst
Volume	141
Issue number	10
DOIs	https://doi.org/10.1039/c5an02650d
Publication status	Published - 21 May 2016

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title = "Ru(II) polypyridyl complex-incorporated and folate-conjugated vehicle for cancer cell imaging and photoinduced inactivation",

abstract = "Ru(ii) polypyridyl complexes have been expected as promising therapeutic agents against cancer owing to its DNA photocleavage activity. However, the lack of cell selectivity poses a significant obstacle to their practical application. Herein, the strategy combining cell-specific imaging with photoinduced cell death based on [Ru(phen)2(dppz)]2+ has been developed by incorporating [Ru(phen)2(dppz)]2+ into folate-conjugated liposomes. The cells overexpressing folate receptors could specifically recognize this vehicle and be imaged through the luminescence of [Ru(phen)2(dppz)]2+. Thereafter, the delivered [Ru(phen)2(dppz)]2+ interacted with DNA in cells and led to photoinduced cell death. This work provided a possible alternative for cancer diagnosis and therapy.",

author = "Huang, {Li Li} and Jin Xu and Jin, {Yong Jie} and Zhao, {Dong Xu} and Xie, {Hai Yan}",

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T1 - Ru(II) polypyridyl complex-incorporated and folate-conjugated vehicle for cancer cell imaging and photoinduced inactivation

AU - Huang, Li Li

AU - Xu, Jin

AU - Jin, Yong Jie

AU - Zhao, Dong Xu

AU - Xie, Hai Yan

PY - 2016/5/21

Y1 - 2016/5/21

N2 - Ru(ii) polypyridyl complexes have been expected as promising therapeutic agents against cancer owing to its DNA photocleavage activity. However, the lack of cell selectivity poses a significant obstacle to their practical application. Herein, the strategy combining cell-specific imaging with photoinduced cell death based on [Ru(phen)2(dppz)]2+ has been developed by incorporating [Ru(phen)2(dppz)]2+ into folate-conjugated liposomes. The cells overexpressing folate receptors could specifically recognize this vehicle and be imaged through the luminescence of [Ru(phen)2(dppz)]2+. Thereafter, the delivered [Ru(phen)2(dppz)]2+ interacted with DNA in cells and led to photoinduced cell death. This work provided a possible alternative for cancer diagnosis and therapy.

AB - Ru(ii) polypyridyl complexes have been expected as promising therapeutic agents against cancer owing to its DNA photocleavage activity. However, the lack of cell selectivity poses a significant obstacle to their practical application. Herein, the strategy combining cell-specific imaging with photoinduced cell death based on [Ru(phen)2(dppz)]2+ has been developed by incorporating [Ru(phen)2(dppz)]2+ into folate-conjugated liposomes. The cells overexpressing folate receptors could specifically recognize this vehicle and be imaged through the luminescence of [Ru(phen)2(dppz)]2+. Thereafter, the delivered [Ru(phen)2(dppz)]2+ interacted with DNA in cells and led to photoinduced cell death. This work provided a possible alternative for cancer diagnosis and therapy.

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Ru(II) polypyridyl complex-incorporated and folate-conjugated vehicle for cancer cell imaging and photoinduced inactivation

Abstract

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