Abstract
By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).
| Original language | English |
|---|---|
| Pages (from-to) | 9-19 |
| Number of pages | 11 |
| Journal | Journal of Asian Natural Products Research |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2021 |
Keywords
- Dregea sinensis
- MS fragmentation pattern
- immunomodulatory activity
- polyoxypregnane glycosides
- structural analysis
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Song, J., Lv, F., Dai, R. J., & Deng, Y. L. (2021). Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSn and HRMS. Journal of Asian Natural Products Research, 23(1), 9-19. https://doi.org/10.1080/10286020.2020.1715951