Peptide functionalized targeting liposomes: For nanoscale drug delivery towards angiogenesis

Qiuju Han, Xiangqian Jia, Yixia Qian, Zihua Wang, Shu Yang, Yunhong Jia*, Weizhi Wang, Zhiyuan Hu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound" (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.

Original languageEnglish
Pages (from-to)7087-7091
Number of pages5
JournalJournal of Materials Chemistry B
Volume4
Issue number44
DOIs
Publication statusPublished - 2016
Externally publishedYes

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Han, Q., Jia, X., Qian, Y., Wang, Z., Yang, S., Jia, Y., Wang, W., & Hu, Z. (2016). Peptide functionalized targeting liposomes: For nanoscale drug delivery towards angiogenesis. Journal of Materials Chemistry B, 4(44), 7087-7091. https://doi.org/10.1039/c6tb01823h