Mono-Sized Anion-Exchange Magnetic Microspheres for Protein Adsorption

Zhe Wang; Wei Wang; Zihui Meng; Min Xue

doi:10.3390/ijms23094963

Mono-Sized Anion-Exchange Magnetic Microspheres for Protein Adsorption

Zhe Wang, Wei Wang, Zihui Meng, Min Xue^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

In this study, mono-sized anion-exchange microspheres with polyglycidylmethacrylate were engineered and processed to introduce magnetic granules by penetration–deposition approaches. The obtained magnetic microspheres showed a uniform particle diameter of 1.235 μm in average and a good spherical shape with a saturation magnetic intensity of 12.48 emu/g by VSM and 12% magnetite content by TGA. The magnetic microspheres showed no cytotoxicity when the concentration was below 10 μg/mg. The magnetic microspheres possess respective adsorption capacity for three proteins including Bovine albumin, Hemoglobin from bovine blood, and Cytochrome C. These magnetic microspheres are also potential biomaterials as targeting medicine carriers or protein separation carriers at low concentration.

Original language	English
Article number	4963
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	9
DOIs	https://doi.org/10.3390/ijms23094963
Publication status	Published - 1 May 2022

Keywords

magnetic microspheres
magnetic separation
protein adsorption
surface embedding

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10.3390/ijms23094963

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abstract = "In this study, mono-sized anion-exchange microspheres with polyglycidylmethacrylate were engineered and processed to introduce magnetic granules by penetration–deposition approaches. The obtained magnetic microspheres showed a uniform particle diameter of 1.235 μm in average and a good spherical shape with a saturation magnetic intensity of 12.48 emu/g by VSM and 12% magnetite content by TGA. The magnetic microspheres showed no cytotoxicity when the concentration was below 10 μg/mg. The magnetic microspheres possess respective adsorption capacity for three proteins including Bovine albumin, Hemoglobin from bovine blood, and Cytochrome C. These magnetic microspheres are also potential biomaterials as targeting medicine carriers or protein separation carriers at low concentration.",

keywords = "magnetic microspheres, magnetic separation, protein adsorption, surface embedding",

author = "Zhe Wang and Wei Wang and Zihui Meng and Min Xue",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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T1 - Mono-Sized Anion-Exchange Magnetic Microspheres for Protein Adsorption

AU - Wang, Zhe

AU - Wang, Wei

AU - Meng, Zihui

AU - Xue, Min

PY - 2022/5/1

Y1 - 2022/5/1

N2 - In this study, mono-sized anion-exchange microspheres with polyglycidylmethacrylate were engineered and processed to introduce magnetic granules by penetration–deposition approaches. The obtained magnetic microspheres showed a uniform particle diameter of 1.235 μm in average and a good spherical shape with a saturation magnetic intensity of 12.48 emu/g by VSM and 12% magnetite content by TGA. The magnetic microspheres showed no cytotoxicity when the concentration was below 10 μg/mg. The magnetic microspheres possess respective adsorption capacity for three proteins including Bovine albumin, Hemoglobin from bovine blood, and Cytochrome C. These magnetic microspheres are also potential biomaterials as targeting medicine carriers or protein separation carriers at low concentration.

AB - In this study, mono-sized anion-exchange microspheres with polyglycidylmethacrylate were engineered and processed to introduce magnetic granules by penetration–deposition approaches. The obtained magnetic microspheres showed a uniform particle diameter of 1.235 μm in average and a good spherical shape with a saturation magnetic intensity of 12.48 emu/g by VSM and 12% magnetite content by TGA. The magnetic microspheres showed no cytotoxicity when the concentration was below 10 μg/mg. The magnetic microspheres possess respective adsorption capacity for three proteins including Bovine albumin, Hemoglobin from bovine blood, and Cytochrome C. These magnetic microspheres are also potential biomaterials as targeting medicine carriers or protein separation carriers at low concentration.

KW - magnetic microspheres

KW - magnetic separation

KW - protein adsorption

KW - surface embedding

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DO - 10.3390/ijms23094963

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SN - 1661-6596

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 9

M1 - 4963

ER -

Mono-Sized Anion-Exchange Magnetic Microspheres for Protein Adsorption

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Keywords

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