Human embryonic development: from peri-implantation to gastrulation

Jinglei Zhai; Zhenyu Xiao; Yiming Wang; Hongmei Wang

doi:10.1016/j.tcb.2021.07.008

Human embryonic development: from peri-implantation to gastrulation

Jinglei Zhai, Zhenyu Xiao, Yiming Wang, Hongmei Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

49 Citations (Scopus)

Abstract

The basic body plan of the mammalian embryo is established through gastrulation, a pivotal early postimplantation event during which the three major germ layers (endoderm, ectoderm, and mesoderm) are specified with cellular and spatial diversity. Despite its basic and clinical importance, human embryo development from peri-implantation to gastrulation remains shrouded in mystery. Recent advances in the elongated in vitro culture of rodent and non-primate embryos and the construction of embryo-like structures have helped to improve understanding of the mechanisms of human early embryonic development. Here, we review the recent advances and possible future directions in the development of in vitro models to better understand human embryogenesis from peri-implantation to gastrulation.

Original language	English
Pages (from-to)	18-29
Number of pages	12
Journal	Trends in Cell Biology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.tcb.2021.07.008
Publication status	Published - Jan 2022
Externally published	Yes

Keywords

gastrulation
human embryonic development
in vitro culture of embryos
peri-implantation
stem cell–based embryo model

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10.1016/j.tcb.2021.07.008

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title = "Human embryonic development: from peri-implantation to gastrulation",

abstract = "The basic body plan of the mammalian embryo is established through gastrulation, a pivotal early postimplantation event during which the three major germ layers (endoderm, ectoderm, and mesoderm) are specified with cellular and spatial diversity. Despite its basic and clinical importance, human embryo development from peri-implantation to gastrulation remains shrouded in mystery. Recent advances in the elongated in vitro culture of rodent and non-primate embryos and the construction of embryo-like structures have helped to improve understanding of the mechanisms of human early embryonic development. Here, we review the recent advances and possible future directions in the development of in vitro models to better understand human embryogenesis from peri-implantation to gastrulation.",

keywords = "gastrulation, human embryonic development, in vitro culture of embryos, peri-implantation, stem cell–based embryo model",

author = "Jinglei Zhai and Zhenyu Xiao and Yiming Wang and Hongmei Wang",

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AU - Xiao, Zhenyu

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AU - Wang, Hongmei

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AB - The basic body plan of the mammalian embryo is established through gastrulation, a pivotal early postimplantation event during which the three major germ layers (endoderm, ectoderm, and mesoderm) are specified with cellular and spatial diversity. Despite its basic and clinical importance, human embryo development from peri-implantation to gastrulation remains shrouded in mystery. Recent advances in the elongated in vitro culture of rodent and non-primate embryos and the construction of embryo-like structures have helped to improve understanding of the mechanisms of human early embryonic development. Here, we review the recent advances and possible future directions in the development of in vitro models to better understand human embryogenesis from peri-implantation to gastrulation.

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Human embryonic development: from peri-implantation to gastrulation

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Keywords

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