Construction of Targeting-Peptide-Based Imaging Reagents and Their Application in Bioimaging

Limin Zhang, Xin Wang, Jinge Zhao, Beilei Sun, Weizhi Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Molecular imaging was developed from basic molecular recognition. It can visualize not only the expression levels of specific molecules in a living system but also specific biological processes, thus providing guidance for early detection and treatment of diseases. As a noninvasive method, imaging agents are one of the foundations of high spatial resolution imaging, and their sensitivity and specificity can be improved by coupling targeting ligands to imaging probes. Among the various targeting ligands (antibodies, aptamers, etc.), targeting peptides are widely used in various modalities of molecular imaging due to their high affinities toward the molecular target and their excellent physicochemical properties. In this review, we summarize the design concepts and methods of targeting peptides in molecular imaging, introduce the combination of targeting peptides and imaging probes in different imaging modalities (e.g., fluorescence imaging, radionuclide imaging), and provide examples of their applications in bioimaging. Finally, the challenges and strategies for clinical translation and practical application of targeting peptide-based imaging reagents are briefly discussed.

Original languageEnglish
Pages (from-to)233-249
Number of pages17
JournalChemical and Biomedical Imaging
Volume2
Issue number4
DOIs
Publication statusPublished - 22 Apr 2024

Keywords

  • De novo design
  • Imaging reagents
  • Molecular imaging
  • OBOC
  • Peptide screening
  • Precise recognition
  • Self-assembly
  • Targeting peptide

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