Cell biocompatibility of functionalized graphene oxide

Xiao Zhang; Rong Yang; Chen Wang; Cheng Lin Heng

doi:10.3866/PKU.WHXB201203131

Cell biocompatibility of functionalized graphene oxide

Xiao Zhang, Rong Yang^*, Chen Wang, Cheng Lin Heng

^*Corresponding author for this work

School of Physics

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

We report on synthesis of nanoscale graphene oxide (NGO) by modified Hummers'method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.

Original language	English
Pages (from-to)	1520-1524
Number of pages	5
Journal	Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica
Volume	28
Issue number	6
DOIs	https://doi.org/10.3866/PKU.WHXB201203131
Publication status	Published - 2012

Keywords

Biocompatibility
Graphene oxide
Nanomaterials
Surface functionalization

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10.3866/PKU.WHXB201203131

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title = "Cell biocompatibility of functionalized graphene oxide",

abstract = "We report on synthesis of nanoscale graphene oxide (NGO) by modified Hummers'method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.",

keywords = "Biocompatibility, Graphene oxide, Nanomaterials, Surface functionalization",

author = "Xiao Zhang and Rong Yang and Chen Wang and Heng, {Cheng Lin}",

year = "2012",

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journal = "Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica",

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T1 - Cell biocompatibility of functionalized graphene oxide

AU - Zhang, Xiao

AU - Yang, Rong

AU - Wang, Chen

AU - Heng, Cheng Lin

PY - 2012

Y1 - 2012

N2 - We report on synthesis of nanoscale graphene oxide (NGO) by modified Hummers'method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.

AB - We report on synthesis of nanoscale graphene oxide (NGO) by modified Hummers'method. Synthesized NGO particles were surface functionalized by attaching carboxylic acid and polyethylene glycol groups to render them soluble in cell culture medium. The structures and properties of functionalized NGO were characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analyzer. Cell viability studies show that PEG-modified NGO particles are highly soluble and incur almost no cytotoxicity to A549 cells, which suggest a great potential for the use of NGO in various biomedical applications.

KW - Biocompatibility

KW - Graphene oxide

KW - Nanomaterials

KW - Surface functionalization

UR - http://www.scopus.com/inward/record.url?scp=84861320783&partnerID=8YFLogxK

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DO - 10.3866/PKU.WHXB201203131

M3 - Article

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SN - 1000-6818

VL - 28

SP - 1520

EP - 1524

JO - Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica

JF - Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica

IS - 6

ER -

Cell biocompatibility of functionalized graphene oxide

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