Zhong, Y., Ma, Z., Zhu, S., Yue, J., Zhang, M., Antaris, A. L., Yuan, J., Cui, R., Wan, H., Zhou, Y., Wang, W., Huang, N. F., Luo, J., Hu, Z., & Dai, H. (2017). Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm. Nature Communications, 8(1), Article 737. https://doi.org/10.1038/s41467-017-00917-6
Zhong, Yeteng ; Ma, Zhuoran ; Zhu, Shoujun et al. / Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm. In: Nature Communications. 2017 ; Vol. 8, No. 1.
@article{c588e2b0185d4b119dad765b6ccdca3f,
title = "Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm",
abstract = "In vivo fluorescence imaging in the near-infrared region between 1500-1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to the suppressed scattering of long-wavelength photons and large fluorophore Stokes shifts. However, very few NIR-IIb fluorescent probes exist currently. Here, we report the synthesis of a down-conversion luminescent rare-earth nanocrystal with cerium doping (Er/Ce co-doped NaYbF4 nanocrystal core with an inert NaYF4 shell). Ce doping is found to suppress the up-conversion pathway while boosting down-conversion by ∼9-fold to produce bright 1550 nm luminescence under 980 nm excitation. Optimization of the inert shell coating surrounding the core and hydrophilic surface functionalization minimize the luminescence quenching effect by water. The resulting biocompatible, bright 1550 nm emitting nanoparticles enable fast in vivo imaging of blood vasculature in the mouse brain and hindlimb in the NIR-IIb window with short exposure time of 20 ms for rare-earth based probes.",
author = "Yeteng Zhong and Zhuoran Ma and Shoujun Zhu and Jingying Yue and Mingxi Zhang and Antaris, {Alexander L.} and Jie Yuan and Ran Cui and Hao Wan and Ying Zhou and Weizhi Wang and Huang, {Ngan F.} and Jian Luo and Zhiyuan Hu and Hongjie Dai",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41467-017-00917-6",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}
Zhong, Y, Ma, Z, Zhu, S, Yue, J, Zhang, M, Antaris, AL, Yuan, J, Cui, R, Wan, H, Zhou, Y, Wang, W, Huang, NF, Luo, J, Hu, Z & Dai, H 2017, 'Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm', Nature Communications, vol. 8, no. 1, 737. https://doi.org/10.1038/s41467-017-00917-6
Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm. / Zhong, Yeteng; Ma, Zhuoran; Zhu, Shoujun et al.
In:
Nature Communications, Vol. 8, No. 1, 737, 01.12.2017.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm
AU - Zhong, Yeteng
AU - Ma, Zhuoran
AU - Zhu, Shoujun
AU - Yue, Jingying
AU - Zhang, Mingxi
AU - Antaris, Alexander L.
AU - Yuan, Jie
AU - Cui, Ran
AU - Wan, Hao
AU - Zhou, Ying
AU - Wang, Weizhi
AU - Huang, Ngan F.
AU - Luo, Jian
AU - Hu, Zhiyuan
AU - Dai, Hongjie
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - In vivo fluorescence imaging in the near-infrared region between 1500-1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to the suppressed scattering of long-wavelength photons and large fluorophore Stokes shifts. However, very few NIR-IIb fluorescent probes exist currently. Here, we report the synthesis of a down-conversion luminescent rare-earth nanocrystal with cerium doping (Er/Ce co-doped NaYbF4 nanocrystal core with an inert NaYF4 shell). Ce doping is found to suppress the up-conversion pathway while boosting down-conversion by ∼9-fold to produce bright 1550 nm luminescence under 980 nm excitation. Optimization of the inert shell coating surrounding the core and hydrophilic surface functionalization minimize the luminescence quenching effect by water. The resulting biocompatible, bright 1550 nm emitting nanoparticles enable fast in vivo imaging of blood vasculature in the mouse brain and hindlimb in the NIR-IIb window with short exposure time of 20 ms for rare-earth based probes.
AB - In vivo fluorescence imaging in the near-infrared region between 1500-1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to the suppressed scattering of long-wavelength photons and large fluorophore Stokes shifts. However, very few NIR-IIb fluorescent probes exist currently. Here, we report the synthesis of a down-conversion luminescent rare-earth nanocrystal with cerium doping (Er/Ce co-doped NaYbF4 nanocrystal core with an inert NaYF4 shell). Ce doping is found to suppress the up-conversion pathway while boosting down-conversion by ∼9-fold to produce bright 1550 nm luminescence under 980 nm excitation. Optimization of the inert shell coating surrounding the core and hydrophilic surface functionalization minimize the luminescence quenching effect by water. The resulting biocompatible, bright 1550 nm emitting nanoparticles enable fast in vivo imaging of blood vasculature in the mouse brain and hindlimb in the NIR-IIb window with short exposure time of 20 ms for rare-earth based probes.
UR - http://www.scopus.com/inward/record.url?scp=85030326484&partnerID=8YFLogxK
U2 - 10.1038/s41467-017-00917-6
DO - 10.1038/s41467-017-00917-6
M3 - Article
C2 - 28963467
AN - SCOPUS:85030326484
SN - 2041-1723
VL - 8
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 737
ER -
Zhong Y, Ma Z, Zhu S, Yue J, Zhang M, Antaris AL et al. Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm. Nature Communications. 2017 Dec 1;8(1):737. doi: 10.1038/s41467-017-00917-6