TY - JOUR
T1 - To export, or not to export
T2 - How nuclear export factor variants resolve Piwi’s dilemma
AU - Wang, Sheng
AU - Lu, Xiaohua
AU - Qiu, Ding
AU - Yu, Yang
N1 - Publisher Copyright:
© 2021 Portland Press Ltd. All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Piwi-interacting RNAs (piRNAs) defend animal gonads by guiding PIWI-clade Argonaute proteins to silence transposons. The nuclear Piwi/piRNA complexes confer transcriptional repression of transposons, which is accompanied with heterochromatin formation at target loci. On the other hand, piRNA clusters, genomic loci that transcribe piRNA precursors composed of transposon fragments, are often recognized by piRNAs to define their heterochromatic identity. Therefore, Piwi/piRNA complexes must resolve this conundrum of silencing transposons while allowing the expression of piRNA precursors, at least in Drosophila germlines. This review is focused on recent advances how the piRNA pathway deals with this genetic conflict.
AB - Piwi-interacting RNAs (piRNAs) defend animal gonads by guiding PIWI-clade Argonaute proteins to silence transposons. The nuclear Piwi/piRNA complexes confer transcriptional repression of transposons, which is accompanied with heterochromatin formation at target loci. On the other hand, piRNA clusters, genomic loci that transcribe piRNA precursors composed of transposon fragments, are often recognized by piRNAs to define their heterochromatic identity. Therefore, Piwi/piRNA complexes must resolve this conundrum of silencing transposons while allowing the expression of piRNA precursors, at least in Drosophila germlines. This review is focused on recent advances how the piRNA pathway deals with this genetic conflict.
UR - http://www.scopus.com/inward/record.url?scp=85118390851&partnerID=8YFLogxK
U2 - 10.1042/BST20201171
DO - 10.1042/BST20201171
M3 - Review article
C2 - 34643228
AN - SCOPUS:85118390851
SN - 0300-5127
VL - 49
SP - 2073
EP - 2079
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
IS - 5
ER -