每年的科研成果
每年的科研成果
个人简介
个人简介
主要研究方向：1）金属蛋白研究工具的开发；2）构建人工金属酶，实现新反应； 3）金属酶反应机理的研究。在国内外学术刊物上发表学术论文20余篇，主持自然科学基金等项目，入选首批中国科协“青年人才托举工程”。
研究领域和方向
主要从事酶工程与化学生物学研究，围绕金属酶催化反应机理不明确，电子传递路径及还原蛋白不清楚的科学问题，通过发展非天然氨基酸进行蛋白质理性设计的研究工具，设计构建激活氧气的血红素蛋白以及参与电子传递的含铜蛋白，并探究反应机理。前期工作中以肌红蛋白为骨架，构建了细胞色素c氧化酶的模型蛋白；基于模型蛋白，研究了关键残基的作用、表征了氧气激活过程中的反应中间体，阐述天然蛋白的机理和电子传递过程；通过电子传递的优化，在国际上首次在人工设计的金属酶中实现了超过天然酶的酶活。
教育背景
2008/8 - 2014/1，伊利诺伊大学香槟分校，生物物理和计算生物学，博士 论文题目: 使用非天然氨基酸进行蛋白质工程研究，导师：陆艺
2004/9 - 2008/7，北京大学，生物科学，学士
2004/9 - 2008/7，北京大学，生物科学，学士
工作履历
2018/3 – 至今: 北京理工大学化学与化工学院，特别研究员
2016/10 - 2018/3，中国科学院，天津工业生物技术研究所，副研究员
2014/3 – 2016/9，中国科学院，天津工业生物技术研究所，助理研究员
2016/10 - 2018/3，中国科学院，天津工业生物技术研究所，副研究员
2014/3 – 2016/9，中国科学院，天津工业生物技术研究所，助理研究员
研究成果
(1) Xiaohong Liu#, Yang Yu#, Cheng Hu, Wei Zhang, Yi Lu*, and Jiangyun Wang*. (2014) Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase. Angew. Chem., Int. Ed. 51, 4312-4316.
(2) Yanchao Pan, Jing-Hua Jin, Yang Yu*, and Jiangyun Wang*. (2014) Significant Enhancement of hPrx1 Chaperone Activity through Lysine Acetylation. ChemBioChem 15, 1773-1776.
(3) Jing Liu#, Saumen Chakraborty#, Parisa Hosseinzadeh#, Yang Yu#, Shiliang Tian, Igor Petrik, Ambika Bhagi, and Yi Lu*. (2014) Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers, Chem. Rev. 114, 4366-4469.
(4) Yang Yu#, Arnab Mukherjee#, Mark J. Nilges, Parisa Hosseinzadeh, Kyle D. Miner, and Yi Lu*. (2014) Direct EPR Observation of a Tyrosyl Radical in a Functional Oxidase Model in Myoglobin during both H2O2 and O2 Reactions. J. Am. Chem. Soc. 136, 1174-1177.
(5) Xiaoxuan Lv#, Yang Yu#, Meng Zhou, Cheng Hu, Feng Gao, Jiasong Li, Xiaohong Liu, Kai Deng, Peng Zheng, Weimin Gong, Andong Xia*, and Jiangyun Wang*. (2015) Ultrafast Photoinduced Electron Transfer in Green Fluorescent Protein Bearing a Genetically Encoded Electron Acceptor. J. Am. Chem. Soc. 137, 7270-7273.
(6) Yang Yu#, Xiaoxuan Lv#, Jiasong Li, Qing Zhou, Chang Cui, Parisa Hosseinzadeh, Arnab Mukherjee, Mark J. Nilges, Jiangyun Wang*, and Yi Lu*. (2015) Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs, J. Am. Chem. Soc. 137, 4594-4597.
(7) Yang Yu#, Qing Zhou#, Li Wang, Xiaohong Liu, Wei Zhang, Meirong Hu, Jianshu Dong, Jiasong Li, Xiaoxuan Lv, Hanlin Ouyang, Han Li, Feng Gao, Weimin Gong, Yi Lu*, and Jiangyun Wang*. (2015) Significant improvement of oxidase activity through the genetic incorporation of a redox-active unnatural amino acid. Chem. Sci. 6, 3881-3885.
(8) Yang Yu#, Chang Cui#, Xiaohong Liu#, Igor D. Petrik, Jiangyun Wang*, and Yi Lu*. (2015) A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme. J. Am. Chem. Soc. 137, 11570-11573.
(9) Cheng Hu#, Yang Yu#, and Jiangyun Wang*. (2017) Improving artificial metalloenzymes' activity by optimizing electron transfer, Chem. Commun. 53, 4173-4186.
(10) Honghui Chen#, Binbin Su, Tongtong Zhang, Aiping Huang, Haiping Liu*, Yang Yu*, and Jiangyun Wang*. (2017) RSC Advances. 7, 56093-56098.
(2) Yanchao Pan, Jing-Hua Jin, Yang Yu*, and Jiangyun Wang*. (2014) Significant Enhancement of hPrx1 Chaperone Activity through Lysine Acetylation. ChemBioChem 15, 1773-1776.
(3) Jing Liu#, Saumen Chakraborty#, Parisa Hosseinzadeh#, Yang Yu#, Shiliang Tian, Igor Petrik, Ambika Bhagi, and Yi Lu*. (2014) Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers, Chem. Rev. 114, 4366-4469.
(4) Yang Yu#, Arnab Mukherjee#, Mark J. Nilges, Parisa Hosseinzadeh, Kyle D. Miner, and Yi Lu*. (2014) Direct EPR Observation of a Tyrosyl Radical in a Functional Oxidase Model in Myoglobin during both H2O2 and O2 Reactions. J. Am. Chem. Soc. 136, 1174-1177.
(5) Xiaoxuan Lv#, Yang Yu#, Meng Zhou, Cheng Hu, Feng Gao, Jiasong Li, Xiaohong Liu, Kai Deng, Peng Zheng, Weimin Gong, Andong Xia*, and Jiangyun Wang*. (2015) Ultrafast Photoinduced Electron Transfer in Green Fluorescent Protein Bearing a Genetically Encoded Electron Acceptor. J. Am. Chem. Soc. 137, 7270-7273.
(6) Yang Yu#, Xiaoxuan Lv#, Jiasong Li, Qing Zhou, Chang Cui, Parisa Hosseinzadeh, Arnab Mukherjee, Mark J. Nilges, Jiangyun Wang*, and Yi Lu*. (2015) Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs, J. Am. Chem. Soc. 137, 4594-4597.
(7) Yang Yu#, Qing Zhou#, Li Wang, Xiaohong Liu, Wei Zhang, Meirong Hu, Jianshu Dong, Jiasong Li, Xiaoxuan Lv, Hanlin Ouyang, Han Li, Feng Gao, Weimin Gong, Yi Lu*, and Jiangyun Wang*. (2015) Significant improvement of oxidase activity through the genetic incorporation of a redox-active unnatural amino acid. Chem. Sci. 6, 3881-3885.
(8) Yang Yu#, Chang Cui#, Xiaohong Liu#, Igor D. Petrik, Jiangyun Wang*, and Yi Lu*. (2015) A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme. J. Am. Chem. Soc. 137, 11570-11573.
(9) Cheng Hu#, Yang Yu#, and Jiangyun Wang*. (2017) Improving artificial metalloenzymes' activity by optimizing electron transfer, Chem. Commun. 53, 4173-4186.
(10) Honghui Chen#, Binbin Su, Tongtong Zhang, Aiping Huang, Haiping Liu*, Yang Yu*, and Jiangyun Wang*. (2017) RSC Advances. 7, 56093-56098.
与联合国可持续发展目标相关的专业知识
2015 年，联合国成员国同意 17 项可持续发展目标 (SDG)，以消除贫困、保护地球并确保全人类的繁荣。此人的工作有助于实现下列可持续发展目标：
指纹图谱
深入其中 Yang Yu 为活跃的研究主题。这些主题标签来自此人的成果。它们共同形成唯一的指纹。
最近五年的合作关系和顶尖研究领域
最近的国家/地区级外部合作关系。点击圆点，以了解详细信息或
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Deciphering Cholesterol's Role in PD-L2 Stability: A Distinct Regulatory Mechanism From PD-L1
Zhang, Y., Xiao, T., Wen, M., Shen, L., Du, L., Wei, S., Wu, B., Yu, Y., Wang, S. & OuYang, B., 15 4月 2024, 在: Journal of Molecular Biology. 436, 8, 168500.科研成果: 期刊稿件 › 文章 › 同行评审
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An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression
Wu, L., Yan, J., Bai, Y., Chen, F., Zou, X., Xu, J., Huang, A., Hou, L., Zhong, Y., Jing, Z., Yu, Q., Zhou, X., Jiang, Z., Wang, C., Cheng, M., Ji, Y., Hou, Y., Luo, R., Li, Q. & Wu, L. 以及 33其他, , 8月 2023, 在: Cell Research. 33, 8, 页码 585-603 19 页码科研成果: 期刊稿件 › 文章 › 同行评审
开放访问50 引用 （Scopus） -
Chromosome-level Asian elephant genome assembly and comparative genomics of long-lived mammals reveal the common substitutions for cancer resistance
Li, X., Wang, P., Pan, Q., Liu, G., Liu, W., Omotoso, O., Du, J., Li, Z., Yu, Y., Huang, Y., Zhu, P., Li, M. & Zhou, X., 9月 2023, 在: Aging Cell. 22, 9, e13917.科研成果: 期刊稿件 › 文章 › 同行评审
开放访问1 引用 （Scopus） -
Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals
Li, M., Du, J., Liu, W., Li, Z., Lv, F., Hu, C., Dai, Y., Zhang, X., Zhang, Z., Liu, G., Pan, Q., Yu, Y., Wang, X., Zhu, P., Tan, X., Garber, P. A. & Zhou, X., 4月 2023, 在: ISME Journal. 17, 4, 页码 549-560 12 页码科研成果: 期刊稿件 › 文章 › 同行评审
开放访问9 引用 （Scopus） -
Correlated evolution of social organization and lifespan in mammals
Zhu, P., Liu, W., Zhang, X., Li, M., Liu, G., Yu, Y., Li, Z., Li, X., Du, J., Wang, X., Grueter, C. C., Li, M. & Zhou, X., 12月 2023, 在: Nature Communications. 14, 1, 372.科研成果: 期刊稿件 › 文章 › 同行评审
开放访问18 引用 （Scopus）