Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

Cong Liu; Rong J. Dai; Guo W. Yao; Yu L. Deng

doi:10.3998/ark.5550190.p008.270

Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

Cong Liu, Rong J. Dai^*, Guo W. Yao, Yu L. Deng

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

9 引用（Scopus）

摘要

The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

源语言	英语
页（从-至）	146-163
页数	18
期刊	Arkivoc
卷	2014
期	4
DOI	https://doi.org/10.3998/ark.5550190.p008.270
出版状态	已出版 - 25 2月 2014

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Liu, C., Dai, R. J., Yao, G. W., & Deng, Y. L. (2014). Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process. Arkivoc, 2014(4), 146-163. https://doi.org/10.3998/ark.5550190.p008.270

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title = "Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process",

abstract = "The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.",

keywords = "Cascade reactions, DMSOHBr oxidation, Debus-Radziszewski condensation, Imidazole synthesis, Pyrazine synthesis",

author = "Cong Liu and Dai, {Rong J.} and Yao, {Guo W.} and Deng, {Yu L.}",

year = "2014",

month = feb,

day = "25",

doi = "10.3998/ark.5550190.p008.270",

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T1 - Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

AU - Liu, Cong

AU - Dai, Rong J.

AU - Yao, Guo W.

AU - Deng, Yu L.

PY - 2014/2/25

Y1 - 2014/2/25

N2 - The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

AB - The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

KW - Cascade reactions

KW - DMSOHBr oxidation

KW - Debus-Radziszewski condensation

KW - Imidazole synthesis

KW - Pyrazine synthesis

UR - http://www.scopus.com/inward/record.url?scp=84896940455&partnerID=8YFLogxK

U2 - 10.3998/ark.5550190.p008.270

DO - 10.3998/ark.5550190.p008.270

M3 - Article

AN - SCOPUS:84896940455

SN - 1551-7004

VL - 2014

SP - 146

EP - 163

JO - Arkivoc

JF - Arkivoc

IS - 4

ER -

Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

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