Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

Cong Liu; Rong J. Dai; Guo W. Yao; Yu L. Deng

doi:10.3998/ark.5550190.p008.270

Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

Cong Liu, Rong J. Dai^*, Guo W. Yao, Yu L. Deng

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

Original language	English
Pages (from-to)	146-163
Number of pages	18
Journal	Arkivoc
Volume	2014
Issue number	4
DOIs	https://doi.org/10.3998/ark.5550190.p008.270
Publication status	Published - 25 Feb 2014

Keywords

Cascade reactions
DMSOHBr oxidation
Debus-Radziszewski condensation
Imidazole synthesis
Pyrazine synthesis

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10.3998/ark.5550190.p008.270

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title = "Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process",

abstract = "The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.",

keywords = "Cascade reactions, DMSOHBr oxidation, Debus-Radziszewski condensation, Imidazole synthesis, Pyrazine synthesis",

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T1 - Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

AU - Liu, Cong

AU - Dai, Rong J.

AU - Yao, Guo W.

AU - Deng, Yu L.

PY - 2014/2/25

Y1 - 2014/2/25

N2 - The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

AB - The synthesis of (4 or 5)-aryl-2-aroyl-1H-imidazoles and 2-hydroxy-3,6-diarylpyrazines from aryl methyl ketones via a cascade process of DMSO-HBr oxidation and Debus reaction was investigated. Owing to the simple starting materials, mild conditions, easy operation, high bioactivity of imidazole and pyrazine derivatives, this protocol has great potential in medicinal chemistry.

KW - Cascade reactions

KW - DMSOHBr oxidation

KW - Debus-Radziszewski condensation

KW - Imidazole synthesis

KW - Pyrazine synthesis

UR - http://www.scopus.com/inward/record.url?scp=84896940455&partnerID=8YFLogxK

U2 - 10.3998/ark.5550190.p008.270

DO - 10.3998/ark.5550190.p008.270

M3 - Article

AN - SCOPUS:84896940455

SN - 1551-7004

VL - 2014

SP - 146

EP - 163

JO - Arkivoc

JF - Arkivoc

IS - 4

ER -

Synthesis of 2-aroyl-(4 or 5)-aryl-1H-imidazoles and 2-hydroxy-3,6-diaryl- pyrazines via a cascade process

Abstract

Keywords

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