Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

Jin Lan Yu, Qin Pei Wu*, Qing Shan Zhang, Yan Hong Liu, Yun Zheng Li, Zi Ming Zhou

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

76 引用 (Scopus)

摘要

A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

源语言英语
页(从-至)240-243
页数4
期刊Bioorganic and Medicinal Chemistry Letters
20
1
DOI
出版状态已出版 - 1 1月 2010

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