Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

Jin Lan Yu; Qin Pei Wu; Qing Shan Zhang; Yan Hong Liu; Yun Zheng Li; Zi Ming Zhou

doi:10.1016/j.bmcl.2009.10.127

Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

Jin Lan Yu, Qin Pei Wu^*, Qing Shan Zhang, Yan Hong Liu, Yun Zheng Li, Zi Ming Zhou

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

Original language	English
Pages (from-to)	240-243
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2009.10.127
Publication status	Published - 1 Jan 2010

Keywords

Antitumor
Nucleoside
Thiol
Triazole

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10.1016/j.bmcl.2009.10.127

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abstract = "A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.",

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AU - Wu, Qin Pei

AU - Zhang, Qing Shan

AU - Liu, Yan Hong

AU - Li, Yun Zheng

AU - Zhou, Zi Ming

PY - 2010/1/1

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AB - A series of novel 2′,3′-dideoxy-2′,3′-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.

KW - Antitumor

KW - Nucleoside

KW - Thiol

KW - Triazole

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ER -

Synthesis and antitumor activity of novel 2′,3′-dideoxy-2′,3′-diethanethionucleosides bearing 1,2,3-triazole residues

Abstract

Keywords

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