Study on synthesis and application of the targeting PLA

Qi Zhang; Qiao Xin Wei; Qiang Wang

Study on synthesis and application of the targeting PLA

Qi Zhang^*, Qiao Xin Wei, Qiang Wang

^*此作品的通讯作者

化学与化工学院

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

In order to solve the poor targeting problems of the traditional micro-particle drug delivery systems, Polylactic acid (PLA) are used and are studied as the membrane materials of the micro-particles. Because folic acid (FOL) is plenty on the surface of the tumor cell, it is used as the receptor and is synthesized to PLA based on the ligand-receptor reaction. Polyethylene glycol (PEG) is used as the medium to connect PLA and FOL together during the synthesis reaction. The result show that the optimal PLA-PEG-FOL is got when the volume ratio of DMSO and CH₃Cl₂ as the solvent is 1:6 and the optimal reaction time is 10 hours. The application study of the PLA-PEG-FOL show that nanoparticle drug delivery system with slippy surface can get at the appropriate preparation condition with appropriate solvent.

源语言	英语
页（从-至）	161-164
页数	4
期刊	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
卷	27
期	SUPPL. 2
出版状态	已出版 - 12月 2007

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@article{816de2fd816f4056838a33c3b9714996,

title = "Study on synthesis and application of the targeting PLA",

abstract = "In order to solve the poor targeting problems of the traditional micro-particle drug delivery systems, Polylactic acid (PLA) are used and are studied as the membrane materials of the micro-particles. Because folic acid (FOL) is plenty on the surface of the tumor cell, it is used as the receptor and is synthesized to PLA based on the ligand-receptor reaction. Polyethylene glycol (PEG) is used as the medium to connect PLA and FOL together during the synthesis reaction. The result show that the optimal PLA-PEG-FOL is got when the volume ratio of DMSO and CH3Cl2 as the solvent is 1:6 and the optimal reaction time is 10 hours. The application study of the PLA-PEG-FOL show that nanoparticle drug delivery system with slippy surface can get at the appropriate preparation condition with appropriate solvent.",

keywords = "Nanoparticle, Polylactic acid (PLA), Polylactic acid-polyethylene glycol-folic acid (PLA-PEG-FOL)",

author = "Qi Zhang and Wei, {Qiao Xin} and Qiang Wang",

year = "2007",

month = dec,

language = "English",

volume = "27",

pages = "161--164",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "SUPPL. 2",

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TY - JOUR

T1 - Study on synthesis and application of the targeting PLA

AU - Zhang, Qi

AU - Wei, Qiao Xin

AU - Wang, Qiang

PY - 2007/12

Y1 - 2007/12

N2 - In order to solve the poor targeting problems of the traditional micro-particle drug delivery systems, Polylactic acid (PLA) are used and are studied as the membrane materials of the micro-particles. Because folic acid (FOL) is plenty on the surface of the tumor cell, it is used as the receptor and is synthesized to PLA based on the ligand-receptor reaction. Polyethylene glycol (PEG) is used as the medium to connect PLA and FOL together during the synthesis reaction. The result show that the optimal PLA-PEG-FOL is got when the volume ratio of DMSO and CH3Cl2 as the solvent is 1:6 and the optimal reaction time is 10 hours. The application study of the PLA-PEG-FOL show that nanoparticle drug delivery system with slippy surface can get at the appropriate preparation condition with appropriate solvent.

AB - In order to solve the poor targeting problems of the traditional micro-particle drug delivery systems, Polylactic acid (PLA) are used and are studied as the membrane materials of the micro-particles. Because folic acid (FOL) is plenty on the surface of the tumor cell, it is used as the receptor and is synthesized to PLA based on the ligand-receptor reaction. Polyethylene glycol (PEG) is used as the medium to connect PLA and FOL together during the synthesis reaction. The result show that the optimal PLA-PEG-FOL is got when the volume ratio of DMSO and CH3Cl2 as the solvent is 1:6 and the optimal reaction time is 10 hours. The application study of the PLA-PEG-FOL show that nanoparticle drug delivery system with slippy surface can get at the appropriate preparation condition with appropriate solvent.

KW - Nanoparticle

KW - Polylactic acid (PLA)

KW - Polylactic acid-polyethylene glycol-folic acid (PLA-PEG-FOL)

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M3 - Article

AN - SCOPUS:40749095242

SN - 1001-0645

VL - 27

SP - 161

EP - 164

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - SUPPL. 2

ER -

Study on synthesis and application of the targeting PLA

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