Abstract
In order to solve the poor targeting problems of the traditional micro-particle drug delivery systems, Polylactic acid (PLA) are used and are studied as the membrane materials of the micro-particles. Because folic acid (FOL) is plenty on the surface of the tumor cell, it is used as the receptor and is synthesized to PLA based on the ligand-receptor reaction. Polyethylene glycol (PEG) is used as the medium to connect PLA and FOL together during the synthesis reaction. The result show that the optimal PLA-PEG-FOL is got when the volume ratio of DMSO and CH3Cl2 as the solvent is 1:6 and the optimal reaction time is 10 hours. The application study of the PLA-PEG-FOL show that nanoparticle drug delivery system with slippy surface can get at the appropriate preparation condition with appropriate solvent.
| Original language | English |
|---|---|
| Pages (from-to) | 161-164 |
| Number of pages | 4 |
| Journal | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology |
| Volume | 27 |
| Issue number | SUPPL. 2 |
| Publication status | Published - Dec 2007 |
Keywords
- Nanoparticle
- Polylactic acid (PLA)
- Polylactic acid-polyethylene glycol-folic acid (PLA-PEG-FOL)