Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain

Hong Zhang, Jun Feng Xiang, Hai Yu Hu, Lin Li, Xue Jin, Yan Liu, Peng Fei Li, Yalin Tang*, Chuan Feng Chen

*此作品的通讯作者

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摘要

A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.

源语言英语
页（从-至）10351-10353
页数3
期刊Biochemistry
卷49
期49
DOI
出版状态已出版 - 14 12月 2010
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Zhang, H., Xiang, J. F., Hu, H. Y., Li, L., Jin, X., Liu, Y., Li, P. F., Tang, Y., & Chen, C. F. (2010). Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain. Biochemistry, 49(49), 10351-10353. https://doi.org/10.1021/bi1001773