Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain

Hong Zhang, Jun Feng Xiang, Hai Yu Hu, Lin Li, Xue Jin, Yan Liu, Peng Fei Li, Yalin Tang*, Chuan Feng Chen

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

9 引用 (Scopus)

摘要

A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.

源语言英语
页(从-至)10351-10353
页数3
期刊Biochemistry
49
49
DOI
出版状态已出版 - 14 12月 2010
已对外发布

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