Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain

Hong Zhang; Jun Feng Xiang; Hai Yu Hu; Lin Li; Xue Jin; Yan Liu; Peng Fei Li; Yalin Tang; Chuan Feng Chen

doi:10.1021/bi1001773

Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain

Hong Zhang, Jun Feng Xiang, Hai Yu Hu, Lin Li, Xue Jin, Yan Liu, Peng Fei Li, Yalin Tang^*, Chuan Feng Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.

Original language	English
Pages (from-to)	10351-10353
Number of pages	3
Journal	Biochemistry
Volume	49
Issue number	49
DOIs	https://doi.org/10.1021/bi1001773
Publication status	Published - 14 Dec 2010
Externally published	Yes

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10.1021/bi1001773

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title = "Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain",

abstract = "A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.",

author = "Hong Zhang and Xiang, {Jun Feng} and Hu, {Hai Yu} and Lin Li and Xue Jin and Yan Liu and Li, {Peng Fei} and Yalin Tang and Chen, {Chuan Feng}",

year = "2010",

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doi = "10.1021/bi1001773",

language = "English",

volume = "49",

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journal = "Biochemistry",

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T1 - Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode

T2 - Cooperation of binaphthylene and the ethoxy chain

AU - Zhang, Hong

AU - Xiang, Jun Feng

AU - Hu, Hai Yu

AU - Li, Lin

AU - Jin, Xue

AU - Liu, Yan

AU - Li, Peng Fei

AU - Tang, Yalin

AU - Chen, Chuan Feng

PY - 2010/12/14

Y1 - 2010/12/14

N2 - A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.

AB - A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=78650139216&partnerID=8YFLogxK

U2 - 10.1021/bi1001773

DO - 10.1021/bi1001773

M3 - Article

C2 - 21073157

AN - SCOPUS:78650139216

SN - 0006-2960

VL - 49

SP - 10351

EP - 10353

JO - Biochemistry

JF - Biochemistry

IS - 49

ER -

Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: Cooperation of binaphthylene and the ethoxy chain

Abstract

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