Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSn and HRMS

Juan Song; Fang Lv; Rong Ji Dai; Yu Lin Deng

doi:10.1080/10286020.2020.1715951

Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSⁿ and HRMS

Juan Song, Fang Lv^*, Rong Ji Dai, Yu Lin Deng

^*此作品的通讯作者

Beijing Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

By HPLC-MSⁿ and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]⁺ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).

源语言	英语
页（从-至）	9-19
页数	11
期刊	Journal of Asian Natural Products Research
卷	23
期	1
DOI	https://doi.org/10.1080/10286020.2020.1715951
出版状态	已出版 - 2021

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Song, J., Lv, F., Dai, R. J., & Deng, Y. L. (2021). Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSⁿ and HRMS. Journal of Asian Natural Products Research, 23(1), 9-19. https://doi.org/10.1080/10286020.2020.1715951

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abstract = "By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).",

keywords = "Dregea sinensis, MS fragmentation pattern, immunomodulatory activity, polyoxypregnane glycosides, structural analysis",

author = "Juan Song and Fang Lv and Dai, {Rong Ji} and Deng, {Yu Lin}",

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AU - Deng, Yu Lin

PY - 2021

Y1 - 2021

N2 - By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).

AB - By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).

KW - Dregea sinensis

KW - MS fragmentation pattern

KW - immunomodulatory activity

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Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSn and HRMS

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Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSⁿ and HRMS