Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSn and HRMS

Juan Song; Fang Lv; Rong Ji Dai; Yu Lin Deng

doi:10.1080/10286020.2020.1715951

Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSⁿ and HRMS

Juan Song, Fang Lv^*, Rong Ji Dai, Yu Lin Deng

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

By HPLC-MSⁿ and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]⁺ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).

Original language	English
Pages (from-to)	9-19
Number of pages	11
Journal	Journal of Asian Natural Products Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1080/10286020.2020.1715951
Publication status	Published - 2021

Keywords

Dregea sinensis
MS fragmentation pattern
immunomodulatory activity
polyoxypregnane glycosides
structural analysis

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10.1080/10286020.2020.1715951

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abstract = "By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).",

keywords = "Dregea sinensis, MS fragmentation pattern, immunomodulatory activity, polyoxypregnane glycosides, structural analysis",

author = "Juan Song and Fang Lv and Dai, {Rong Ji} and Deng, {Yu Lin}",

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AU - Lv, Fang

AU - Dai, Rong Ji

AU - Deng, Yu Lin

PY - 2021

Y1 - 2021

N2 - By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).

AB - By HPLC-MSn and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Dregea sinensis Hemsl on the basis of their sodium-cationized molecules [M + Na]+ and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds 1 and 7 significantly inhibited LPS-stimulated splenocyte proliferation in vitro. (Figure presented.).

KW - Dregea sinensis

KW - MS fragmentation pattern

KW - immunomodulatory activity

KW - polyoxypregnane glycosides

KW - structural analysis

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JF - Journal of Asian Natural Products Research

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Rapid identification and structural characterization of polyoxypregnane glycosides in Dregea sinensis by HPLC-MSⁿ and HRMS

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Keywords

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