Mitochondria-specific ultrasensitive ratiometric AIE probe for imaging endogenous peroxynitrite

Bingpeng Guo; Wei Shu; Wenjie Liu; Hong Wang; Shu Xing; Jianbin Chen; Xiaoling Zhang

doi:10.1016/j.snb.2021.130206

Mitochondria-specific ultrasensitive ratiometric AIE probe for imaging endogenous peroxynitrite

Bingpeng Guo^*, Wei Shu, Wenjie Liu, Hong Wang, Shu Xing, Jianbin Chen, Xiaoling Zhang

^*此作品的通讯作者

化学与化工学院

科研成果: 期刊稿件 › 文章 › 同行评审

44 引用（Scopus）

摘要

Peroxynitrite (ONOO⁻), one of well-known highly reactive oxygen and nitrogen species, is closely related to a quantity of pathological and physiological activities. Studies indicated that mitochondria were the main organelles for the ONOO⁻ production. Therefore, accurately detecting the fluctuations of mitochondrial ONOO⁻ significantly effect in revealing the mechanism of ONOO⁻ in living systems. In this research, a ratiometric fluorescent probe TPE-BOH with AIE characteristic was developed for detecting of ONOO⁻ in living cells. AIEgen TPE-BOH exhibited a quantitative response to ONOO⁻ (50–300 nM) with an ultra-low detection limit (0.45 nM). Remarkably, due to the good biocompatibility and excellent mitochondria-targeted ability of TPE-BOH, it was successfully employed to ratiometric image the fluctuations of ONOO⁻ in mitochondria.

源语言	英语
文章编号	130206
期刊	Sensors and Actuators, B: Chemical
卷	344
DOI	https://doi.org/10.1016/j.snb.2021.130206
出版状态	已出版 - 1 10月 2021

访问文件

10.1016/j.snb.2021.130206

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{6d75b6e6419f45279e60c5019533d197,

title = "Mitochondria-specific ultrasensitive ratiometric AIE probe for imaging endogenous peroxynitrite",

abstract = "Peroxynitrite (ONOO−), one of well-known highly reactive oxygen and nitrogen species, is closely related to a quantity of pathological and physiological activities. Studies indicated that mitochondria were the main organelles for the ONOO− production. Therefore, accurately detecting the fluctuations of mitochondrial ONOO− significantly effect in revealing the mechanism of ONOO− in living systems. In this research, a ratiometric fluorescent probe TPE-BOH with AIE characteristic was developed for detecting of ONOO− in living cells. AIEgen TPE-BOH exhibited a quantitative response to ONOO− (50–300 nM) with an ultra-low detection limit (0.45 nM). Remarkably, due to the good biocompatibility and excellent mitochondria-targeted ability of TPE-BOH, it was successfully employed to ratiometric image the fluctuations of ONOO− in mitochondria.",

keywords = "AIEgen, Mitochondria, ONOO, Ratiometric, Ultrasensitive",

author = "Bingpeng Guo and Wei Shu and Wenjie Liu and Hong Wang and Shu Xing and Jianbin Chen and Xiaoling Zhang",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = oct,

day = "1",

doi = "10.1016/j.snb.2021.130206",

language = "English",

volume = "344",

journal = "Sensors and Actuators, B: Chemical",

issn = "0925-4005",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Mitochondria-specific ultrasensitive ratiometric AIE probe for imaging endogenous peroxynitrite

AU - Guo, Bingpeng

AU - Shu, Wei

AU - Liu, Wenjie

AU - Wang, Hong

AU - Xing, Shu

AU - Chen, Jianbin

AU - Zhang, Xiaoling

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Peroxynitrite (ONOO−), one of well-known highly reactive oxygen and nitrogen species, is closely related to a quantity of pathological and physiological activities. Studies indicated that mitochondria were the main organelles for the ONOO− production. Therefore, accurately detecting the fluctuations of mitochondrial ONOO− significantly effect in revealing the mechanism of ONOO− in living systems. In this research, a ratiometric fluorescent probe TPE-BOH with AIE characteristic was developed for detecting of ONOO− in living cells. AIEgen TPE-BOH exhibited a quantitative response to ONOO− (50–300 nM) with an ultra-low detection limit (0.45 nM). Remarkably, due to the good biocompatibility and excellent mitochondria-targeted ability of TPE-BOH, it was successfully employed to ratiometric image the fluctuations of ONOO− in mitochondria.

AB - Peroxynitrite (ONOO−), one of well-known highly reactive oxygen and nitrogen species, is closely related to a quantity of pathological and physiological activities. Studies indicated that mitochondria were the main organelles for the ONOO− production. Therefore, accurately detecting the fluctuations of mitochondrial ONOO− significantly effect in revealing the mechanism of ONOO− in living systems. In this research, a ratiometric fluorescent probe TPE-BOH with AIE characteristic was developed for detecting of ONOO− in living cells. AIEgen TPE-BOH exhibited a quantitative response to ONOO− (50–300 nM) with an ultra-low detection limit (0.45 nM). Remarkably, due to the good biocompatibility and excellent mitochondria-targeted ability of TPE-BOH, it was successfully employed to ratiometric image the fluctuations of ONOO− in mitochondria.

KW - AIEgen

KW - Mitochondria

KW - ONOO

KW - Ratiometric

KW - Ultrasensitive

UR - http://www.scopus.com/inward/record.url?scp=85107275705&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2021.130206

DO - 10.1016/j.snb.2021.130206

M3 - Article

AN - SCOPUS:85107275705

SN - 0925-4005

VL - 344

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

M1 - 130206

ER -

Mitochondria-specific ultrasensitive ratiometric AIE probe for imaging endogenous peroxynitrite

摘要

访问文件

其它文件与链接

指纹

引用此