@inproceedings{eb685c2818fc4c499f8e5858d862df69,
title = "Glycogen synthase kinase-3β facilitates cell apoptosis induced by high fluence low-power laser irradiation through acceleration of Bax translocation",
abstract = "Glycogen synthase kinase-3β (GSK-3β) is a critical activator of cell apoptosis induced by a diverse array of insults. However, the effects of GSK-3β on the human lung adenocarcinoma cell (ASTC-a-1) apoptosis induced by high fluence low-power laser irradiation (HF-LPLI) are not clear. Here, we showed that GSK-3β was constantly translocated from cytoplasm to nucleus and activated during HF-LPLI-induced cell apoptosis. In addition, we found that co-overexpression of YFP-GSK-3β and CFP-Bax in ASTC-a-1 cells accelerated both Bax translocations to mitochondria and cell apoptosis, compared to the cells expressed CFP-Bax only under HF-LPLI treatment, indicating that GSK-3β facilitated ASTC-a-1 cells apoptosis through acceleration mitochondrial translocation of Bax. Our results demonstrate that GSK-3β exerts some of its pro-apoptotic effects in ASTC-a-1 cells by regulating the mitochondrial localization of Bax, a key component of the intrinsic apoptotic cascade.",
keywords = "Apoptosis, Bax, GSK-3β, HF-LPLI",
author = "Lei Huang and Shengnan Wu and Da Xing",
year = "2011",
doi = "10.1117/12.874138",
language = "English",
isbn = "9780819484246",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Mechanisms for Low-Light Therapy VI",
note = "Mechanisms for Low-Light Therapy VI ; Conference date: 22-01-2011 Through 23-01-2011",
}