Feasibility Study of Label-Free Raman Spectroscopy for Parathyroid Gland Identification

Hao Wang, Sisi Guo, Ruoyu Zhang*, Jing Yao, Wen Tian*, Jianfeng Wang

*此作品的通讯作者

科研成果: 期刊稿件文章同行评审

摘要

We aim to evaluate the feasibility of Raman spectroscopy for parathyroid gland (PG) identification during thyroidectomy. Using a novel side-viewing handheld Raman probe, a total of 324 Raman spectra of four tissue types (i.e., thyroid, lymph node, PG, and lipid) commonly encountered during thyroidectomy were rapidly (< 3 s) acquired from 80 tissue sites (thyroid [n = 10], lymph node [n = 10], PG [n = 40], lipid [n = 20]) of 10 euthanized Wistar rats. Two partial least-squares (PLS)-discriminant analysis (DA) detection models were developed, differentiating the lipid and nonlipid (i.e., thyroid, lymph node, and PG) tissues with an accuracy of 100%, and PG, lymph node, and thyroid could be detected with an accuracy of 98.4%, 93.9%, and 95.4% respectively. This work demonstrates the feasibility of Raman spectroscopy technique for PG identification and protection during thyroidectomy at the molecular level.

源语言英语
文章编号e202400220
期刊Journal of Biophotonics
18
1
DOI
出版状态已出版 - 1月 2025

指纹

探究 'Feasibility Study of Label-Free Raman Spectroscopy for Parathyroid Gland Identification' 的科研主题。它们共同构成独一无二的指纹。

引用此

Wang, H., Guo, S., Zhang, R., Yao, J., Tian, W., & Wang, J. (2025). Feasibility Study of Label-Free Raman Spectroscopy for Parathyroid Gland Identification. Journal of Biophotonics, 18(1), 文章 e202400220. https://doi.org/10.1002/jbio.202400220